Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048587542> ?p ?o ?g. }
- W3048587542 abstract "An early diagnosis of hepatocellular carcinoma (HCC) followed by effective treatment is currently critical for improving the prognosis and reducing the associated economic burden. Alpha-fetoprotein (AFP) is the most widely used biomarker for HCC diagnosis. Based on elevated serum AFP levels as well as typical imaging features, AFP-positive HCC (APHC) can be easily diagnosed, but AFP-negative HCC (ANHC) is not easily detected due to lack of ideal biomarkers and thus mainly reliance on imaging. Imaging for the diagnosis of ANHC is probably insufficient in sensitivity and / or specificity because most ANHC tumors are small and early-stage HCC, and involves in sophisticated techniques and high costs. Moreover, ANHC accounts for nearly half of HCC and exhibits a better prognosis compared with APHC. Therefore, the diagnosis of ANHC in clinical practice has been a critical issue for the early treatment and prognosis improvement of HCC. In recent years, tremendous efforts have been made to discover new biomarkers complementary to AFP for HCC diagnosis. In this review, we systematically review and discuss the recent advances of blood biomarkers for HCC diagnosis, including DNA biomarkers, RNA biomarkers, protein biomarkers and conventional laboratory metrics, focusing on their diagnostic evaluation alone and in combination, in particular on their diagnostic performance for ANHC." @default.
- W3048587542 created "2020-08-18" @default.
- W3048587542 creator A5034237761 @default.
- W3048587542 creator A5068080767 @default.
- W3048587542 date "2020-08-14" @default.
- W3048587542 modified "2023-10-18" @default.
- W3048587542 title "New Blood Biomarkers for the Diagnosis of AFP-Negative Hepatocellular Carcinoma" @default.
- W3048587542 cites W142529164 @default.
- W3048587542 cites W1513044495 @default.
- W3048587542 cites W1550767186 @default.
- W3048587542 cites W1566879104 @default.
- W3048587542 cites W1571309209 @default.
- W3048587542 cites W1572607517 @default.
- W3048587542 cites W1590094217 @default.
- W3048587542 cites W1789551760 @default.
- W3048587542 cites W1950525105 @default.
- W3048587542 cites W1965512352 @default.
- W3048587542 cites W1972162901 @default.
- W3048587542 cites W1975334915 @default.
- W3048587542 cites W1975487068 @default.
- W3048587542 cites W1977423206 @default.
- W3048587542 cites W1977521791 @default.
- W3048587542 cites W1980346895 @default.
- W3048587542 cites W1984172615 @default.
- W3048587542 cites W1984582281 @default.
- W3048587542 cites W1984780485 @default.
- W3048587542 cites W1985786835 @default.
- W3048587542 cites W1985805774 @default.
- W3048587542 cites W1987525830 @default.
- W3048587542 cites W1989480741 @default.
- W3048587542 cites W1990893849 @default.
- W3048587542 cites W1991182374 @default.
- W3048587542 cites W1996302441 @default.
- W3048587542 cites W1999646901 @default.
- W3048587542 cites W2000185144 @default.
- W3048587542 cites W2001363113 @default.
- W3048587542 cites W2001795292 @default.
- W3048587542 cites W2003445065 @default.
- W3048587542 cites W2005010556 @default.
- W3048587542 cites W2011553121 @default.
- W3048587542 cites W2012724001 @default.
- W3048587542 cites W2014754886 @default.
- W3048587542 cites W2022161771 @default.
- W3048587542 cites W2031515391 @default.
- W3048587542 cites W2031930309 @default.
- W3048587542 cites W2036291381 @default.
- W3048587542 cites W2037093159 @default.
- W3048587542 cites W2038847758 @default.
- W3048587542 cites W2041268211 @default.
- W3048587542 cites W2042063670 @default.
- W3048587542 cites W2046157594 @default.
- W3048587542 cites W2046246310 @default.
- W3048587542 cites W2047146435 @default.
- W3048587542 cites W2049170771 @default.
- W3048587542 cites W2049916365 @default.
- W3048587542 cites W2062117233 @default.
- W3048587542 cites W2063233376 @default.
- W3048587542 cites W2070778756 @default.
- W3048587542 cites W2070889802 @default.
- W3048587542 cites W2073128913 @default.
- W3048587542 cites W2076340477 @default.
- W3048587542 cites W2081277484 @default.
- W3048587542 cites W2082184188 @default.
- W3048587542 cites W2082424848 @default.
- W3048587542 cites W2084262557 @default.
- W3048587542 cites W2084868600 @default.
- W3048587542 cites W2086454839 @default.
- W3048587542 cites W2087238991 @default.
- W3048587542 cites W2088128227 @default.
- W3048587542 cites W2089072825 @default.
- W3048587542 cites W2092589546 @default.
- W3048587542 cites W2096066755 @default.
- W3048587542 cites W2096767066 @default.
- W3048587542 cites W2097915189 @default.
- W3048587542 cites W2100545793 @default.
- W3048587542 cites W2108203277 @default.
- W3048587542 cites W2110694062 @default.
- W3048587542 cites W2110806607 @default.
- W3048587542 cites W2113035533 @default.
- W3048587542 cites W2115978612 @default.
- W3048587542 cites W2120963150 @default.
- W3048587542 cites W2121289930 @default.
- W3048587542 cites W2124634982 @default.
- W3048587542 cites W2125580750 @default.
- W3048587542 cites W2126020449 @default.
- W3048587542 cites W2134841349 @default.
- W3048587542 cites W2135281397 @default.
- W3048587542 cites W2137285153 @default.
- W3048587542 cites W2139893628 @default.
- W3048587542 cites W2141680358 @default.
- W3048587542 cites W2142867416 @default.
- W3048587542 cites W2146685970 @default.
- W3048587542 cites W2149039098 @default.
- W3048587542 cites W2149249150 @default.
- W3048587542 cites W2149628902 @default.
- W3048587542 cites W2149659371 @default.
- W3048587542 cites W2154334123 @default.
- W3048587542 cites W2156029072 @default.
- W3048587542 cites W2156447080 @default.
- W3048587542 cites W2160357325 @default.