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- W3048588367 abstract "Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles for astrocytes in immune cell crosstalk. Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles for astrocytes in immune cell crosstalk. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit ActivitiesHuang et al.NeuronApril 21, 2020In BriefAstrocytes play essential roles in brain function by supporting synaptic connectivity and associated circuits. We found the transcription factor NFIA is required to maintain astrocyte function in the hippocampus through region-specific DNA binding mechanisms. Alterations in astrocyte-neuron communication disrupt hippocampal circuit function, resulting in impaired learning and memory behaviors. Full-Text PDF Open Archive" @default.
- W3048588367 created "2020-08-18" @default.
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- W3048588367 date "2020-09-01" @default.
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- W3048588367 title "Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity" @default.
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- W3048588367 doi "https://doi.org/10.1016/j.it.2020.07.011" @default.
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