Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048591630> ?p ?o ?g. }
- W3048591630 endingPage "960" @default.
- W3048591630 startingPage "947" @default.
- W3048591630 abstract "Many lncRNAs are transcribed by dysregulated RNA polymerase II and are inefficiently spliced, leading to preferred nuclear localization patterns. Exonic repeats, C-rich motifs, and U1 motifs in lncRNAs promote their specific nuclear localization and function. Trans-factors such as hnRNPs, RNA helicases, and splicing factors facilitate lncRNA nuclear localization by interacting with different cis-acting motifs. The subcellular localization of lncRNA orthologs is regulated during evolution. Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and biological processes. The subcellular localization of lncRNAs determines their modes of action. Compared to mRNAs, however, many mRNA-like lncRNAs are preferentially localized to the nucleus where they regulate chromatin organization, transcription, and different nuclear condensates. Recent studies have revealed the complex mechanisms that govern lncRNA nuclear retention. We review current understanding of how the transcription and processing of lncRNAs, motifs within lncRNAs, and trans-factors coordinately contribute to their nuclear retention in mammalian cells. Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and biological processes. The subcellular localization of lncRNAs determines their modes of action. Compared to mRNAs, however, many mRNA-like lncRNAs are preferentially localized to the nucleus where they regulate chromatin organization, transcription, and different nuclear condensates. Recent studies have revealed the complex mechanisms that govern lncRNA nuclear retention. We review current understanding of how the transcription and processing of lncRNAs, motifs within lncRNAs, and trans-factors coordinately contribute to their nuclear retention in mammalian cells." @default.
- W3048591630 created "2020-08-18" @default.
- W3048591630 creator A5067820974 @default.
- W3048591630 creator A5071369567 @default.
- W3048591630 creator A5085202900 @default.
- W3048591630 date "2020-11-01" @default.
- W3048591630 modified "2023-10-16" @default.
- W3048591630 title "Mechanisms of Long Noncoding RNA Nuclear Retention" @default.
- W3048591630 cites W1540853973 @default.
- W3048591630 cites W1793796070 @default.
- W3048591630 cites W1879996757 @default.
- W3048591630 cites W1966411071 @default.
- W3048591630 cites W1971641541 @default.
- W3048591630 cites W1972104572 @default.
- W3048591630 cites W1985233638 @default.
- W3048591630 cites W1994943629 @default.
- W3048591630 cites W1997535872 @default.
- W3048591630 cites W2003719212 @default.
- W3048591630 cites W2008542507 @default.
- W3048591630 cites W2014432315 @default.
- W3048591630 cites W2030658020 @default.
- W3048591630 cites W2034518808 @default.
- W3048591630 cites W2034567135 @default.
- W3048591630 cites W2037363723 @default.
- W3048591630 cites W2050982262 @default.
- W3048591630 cites W2051282896 @default.
- W3048591630 cites W2051848082 @default.
- W3048591630 cites W2058970225 @default.
- W3048591630 cites W2059864757 @default.
- W3048591630 cites W2072863253 @default.
- W3048591630 cites W2076825429 @default.
- W3048591630 cites W2087166511 @default.
- W3048591630 cites W2087528029 @default.
- W3048591630 cites W2087587381 @default.
- W3048591630 cites W2088069070 @default.
- W3048591630 cites W2090227993 @default.
- W3048591630 cites W2100582928 @default.
- W3048591630 cites W2101177674 @default.
- W3048591630 cites W2107454957 @default.
- W3048591630 cites W2108012214 @default.
- W3048591630 cites W2109048721 @default.
- W3048591630 cites W2109293112 @default.
- W3048591630 cites W2109632198 @default.
- W3048591630 cites W2122576011 @default.
- W3048591630 cites W2128019463 @default.
- W3048591630 cites W2133205331 @default.
- W3048591630 cites W2134625814 @default.
- W3048591630 cites W2135246959 @default.
- W3048591630 cites W2135302954 @default.
- W3048591630 cites W2141831115 @default.
- W3048591630 cites W2147524392 @default.
- W3048591630 cites W2148393113 @default.
- W3048591630 cites W2149710757 @default.
- W3048591630 cites W2153268494 @default.
- W3048591630 cites W2153833484 @default.
- W3048591630 cites W2156880688 @default.
- W3048591630 cites W2160333540 @default.
- W3048591630 cites W2164956931 @default.
- W3048591630 cites W2166810745 @default.
- W3048591630 cites W2171237426 @default.
- W3048591630 cites W2174605830 @default.
- W3048591630 cites W2237493771 @default.
- W3048591630 cites W2311921258 @default.
- W3048591630 cites W2319972745 @default.
- W3048591630 cites W2329506014 @default.
- W3048591630 cites W2401436717 @default.
- W3048591630 cites W2505384565 @default.
- W3048591630 cites W2511664109 @default.
- W3048591630 cites W2540143287 @default.
- W3048591630 cites W2555415447 @default.
- W3048591630 cites W2559801043 @default.
- W3048591630 cites W2560534389 @default.
- W3048591630 cites W2566261809 @default.
- W3048591630 cites W2567665210 @default.
- W3048591630 cites W2610181528 @default.
- W3048591630 cites W2625283862 @default.
- W3048591630 cites W2746147763 @default.
- W3048591630 cites W2752515767 @default.
- W3048591630 cites W2752702534 @default.
- W3048591630 cites W2754070500 @default.
- W3048591630 cites W2754312617 @default.
- W3048591630 cites W2754846502 @default.
- W3048591630 cites W2769039165 @default.
- W3048591630 cites W2779109505 @default.
- W3048591630 cites W2784570320 @default.
- W3048591630 cites W2790085226 @default.
- W3048591630 cites W2806725605 @default.
- W3048591630 cites W2807912841 @default.
- W3048591630 cites W2891242171 @default.
- W3048591630 cites W2898603273 @default.
- W3048591630 cites W2905856787 @default.
- W3048591630 cites W2912245607 @default.
- W3048591630 cites W2913683218 @default.
- W3048591630 cites W2918407275 @default.
- W3048591630 cites W2943588752 @default.
- W3048591630 cites W2944901478 @default.
- W3048591630 cites W2945294402 @default.
- W3048591630 cites W2948798152 @default.