Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048593624> ?p ?o ?g. }
- W3048593624 abstract "Abstract Mycoplasma hyopneumoniae is the most costly pathogen for swine production. Although several studies have focused on the host-bacterium association, little is known about the changes in gene expression of swine cells upon infection. To improve our understanding of this interaction, we infected swine epithelial NPTr cells with M. hyopneumoniae strain J to identify differentially expressed mRNAs and miRNAs. The levels of 1,268 genes and 170 miRNAs were significantly modified post-infection. Up-regulated mRNAs were enriched in genes related to redox homeostasis and antioxidant defense, known to be regulated by the transcription factor NRF2 in related species. Down-regulated mRNAs were enriched in genes associated with cytoskeleton and ciliary functions. Bioinformatic analyses suggested a correlation between changes in miRNA and mRNA levels, since we detected down-regulation of miRNAs predicted to target antioxidant genes and up-regulation of miRNAs targeting ciliary and cytoskeleton genes. Interestingly, most down-regulated miRNAs were detected in exosome-like vesicles suggesting that M. hyopneumoniae infection induced a modification of the composition of NPTr-released vesicles. Taken together, our data indicate that M. hyopneumoniae elicits an antioxidant response induced by NRF2 in infected cells. In addition, we propose that ciliostasis caused by this pathogen is partially explained by the down-regulation of ciliary genes." @default.
- W3048593624 created "2020-08-18" @default.
- W3048593624 creator A5006451791 @default.
- W3048593624 creator A5028602536 @default.
- W3048593624 creator A5038821066 @default.
- W3048593624 creator A5043817766 @default.
- W3048593624 creator A5044540605 @default.
- W3048593624 creator A5049270978 @default.
- W3048593624 creator A5067032187 @default.
- W3048593624 creator A5079766156 @default.
- W3048593624 creator A5087380201 @default.
- W3048593624 date "2020-08-13" @default.
- W3048593624 modified "2023-09-25" @default.
- W3048593624 title "Mycoplasma hyopneumoniae J elicits an antioxidant response and decreases the expression of ciliary genes in infected swine epithelial cells" @default.
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