Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048596164> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3048596164 abstract "Structure determination is key to understanding protein function at a molecular level. Whilst significant advances have been made in predicting structure and function from amino acid sequence, researchers must still rely on expensive, time-consuming analytical methods to visualise detailed protein conformation. In this study, we demonstrate that it is possible to make accurate predictions of protein fold taxonomy from structures determined at low ($>$3 Angstroms) resolution, using a deep convolutional neural network trained on high-resolution structures ($leq$3 Angstroms). Thus, we provide proof of concept for high-speed, low-cost protein structure classification at low resolution. We explore the relationship between the information content of the input image and the predictive power of the model, achieving state of the art performance on homologous superfamily prediction with maps of interatomic distance. Our findings contribute further evidence that inclusion of both amino acid alpha and beta carbon geometry in these maps improves classification performance over purely alpha carbon representations, and show that side-chain information may not be necessary for fine-grained structure predictions. Finally, we confirm that high-resolution, low-resolution and NMR-determined structures inhabit a common feature space, and thus provide a theoretical basis for mapping between domains to boost resolution." @default.
- W3048596164 created "2020-08-18" @default.
- W3048596164 creator A5007355377 @default.
- W3048596164 creator A5039302902 @default.
- W3048596164 date "2020-08-11" @default.
- W3048596164 modified "2023-09-27" @default.
- W3048596164 title "Transfer Learning for Protein Structure Classification and Function Inference at Low Resolution" @default.
- W3048596164 hasPublicationYear "2020" @default.
- W3048596164 type Work @default.
- W3048596164 sameAs 3048596164 @default.
- W3048596164 citedByCount "0" @default.
- W3048596164 crossrefType "posted-content" @default.
- W3048596164 hasAuthorship W3048596164A5007355377 @default.
- W3048596164 hasAuthorship W3048596164A5039302902 @default.
- W3048596164 hasConcept C11413529 @default.
- W3048596164 hasConcept C119857082 @default.
- W3048596164 hasConcept C121332964 @default.
- W3048596164 hasConcept C138268822 @default.
- W3048596164 hasConcept C14036430 @default.
- W3048596164 hasConcept C153180895 @default.
- W3048596164 hasConcept C154945302 @default.
- W3048596164 hasConcept C18051474 @default.
- W3048596164 hasConcept C185592680 @default.
- W3048596164 hasConcept C205649164 @default.
- W3048596164 hasConcept C2776214188 @default.
- W3048596164 hasConcept C3019883945 @default.
- W3048596164 hasConcept C3020199158 @default.
- W3048596164 hasConcept C37407028 @default.
- W3048596164 hasConcept C41008148 @default.
- W3048596164 hasConcept C46141821 @default.
- W3048596164 hasConcept C47701112 @default.
- W3048596164 hasConcept C62649853 @default.
- W3048596164 hasConcept C78458016 @default.
- W3048596164 hasConcept C8010536 @default.
- W3048596164 hasConcept C81363708 @default.
- W3048596164 hasConcept C86803240 @default.
- W3048596164 hasConceptScore W3048596164C11413529 @default.
- W3048596164 hasConceptScore W3048596164C119857082 @default.
- W3048596164 hasConceptScore W3048596164C121332964 @default.
- W3048596164 hasConceptScore W3048596164C138268822 @default.
- W3048596164 hasConceptScore W3048596164C14036430 @default.
- W3048596164 hasConceptScore W3048596164C153180895 @default.
- W3048596164 hasConceptScore W3048596164C154945302 @default.
- W3048596164 hasConceptScore W3048596164C18051474 @default.
- W3048596164 hasConceptScore W3048596164C185592680 @default.
- W3048596164 hasConceptScore W3048596164C205649164 @default.
- W3048596164 hasConceptScore W3048596164C2776214188 @default.
- W3048596164 hasConceptScore W3048596164C3019883945 @default.
- W3048596164 hasConceptScore W3048596164C3020199158 @default.
- W3048596164 hasConceptScore W3048596164C37407028 @default.
- W3048596164 hasConceptScore W3048596164C41008148 @default.
- W3048596164 hasConceptScore W3048596164C46141821 @default.
- W3048596164 hasConceptScore W3048596164C47701112 @default.
- W3048596164 hasConceptScore W3048596164C62649853 @default.
- W3048596164 hasConceptScore W3048596164C78458016 @default.
- W3048596164 hasConceptScore W3048596164C8010536 @default.
- W3048596164 hasConceptScore W3048596164C81363708 @default.
- W3048596164 hasConceptScore W3048596164C86803240 @default.
- W3048596164 hasLocation W30485961641 @default.
- W3048596164 hasOpenAccess W3048596164 @default.
- W3048596164 hasPrimaryLocation W30485961641 @default.
- W3048596164 hasRelatedWork W1971080751 @default.
- W3048596164 hasRelatedWork W1987104859 @default.
- W3048596164 hasRelatedWork W2020730970 @default.
- W3048596164 hasRelatedWork W2048996867 @default.
- W3048596164 hasRelatedWork W2185380528 @default.
- W3048596164 hasRelatedWork W2257612465 @default.
- W3048596164 hasRelatedWork W2315362862 @default.
- W3048596164 hasRelatedWork W2398209148 @default.
- W3048596164 hasRelatedWork W2477436522 @default.
- W3048596164 hasRelatedWork W2508241396 @default.
- W3048596164 hasRelatedWork W2894624059 @default.
- W3048596164 hasRelatedWork W2937569020 @default.
- W3048596164 hasRelatedWork W2948328253 @default.
- W3048596164 hasRelatedWork W2954705142 @default.
- W3048596164 hasRelatedWork W3005695231 @default.
- W3048596164 hasRelatedWork W3095586736 @default.
- W3048596164 hasRelatedWork W3101075981 @default.
- W3048596164 hasRelatedWork W3157473273 @default.
- W3048596164 hasRelatedWork W3203267898 @default.
- W3048596164 hasRelatedWork W47596674 @default.
- W3048596164 isParatext "false" @default.
- W3048596164 isRetracted "false" @default.
- W3048596164 magId "3048596164" @default.
- W3048596164 workType "article" @default.