Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048598321> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W3048598321 abstract "Review of materials related to scientific principles underlying clinical trials of coagulation factor IX medications obtained using recombinant DNA technique or from donors’ blood plasma. Inherited deficiency of functional active coagulation factor IX or a low level of its synthesis lead to the development of hemophilia B. Patients with hemophilia require a continuous replacement therapy with factor IX medications. Achievements in the area of genetically engineering technologies as well as improvement of production process of biological products allow developing modern highly efficient medications which are successfully used to treat patients with hemophilia. Registration of newly developed medications and medications produced according to the modified technology requires clinical trials. Principles of these trials are regulated by the clauses of regularly updated regulatory documents. Compliance with national and international guidelines determining the conditions for clini‑ cal trials of medications allows us to guarantee their safety and promotes the development of medications efficient to treat patients with hemophilia." @default.
- W3048598321 created "2020-08-18" @default.
- W3048598321 creator A5023787037 @default.
- W3048598321 creator A5040970290 @default.
- W3048598321 creator A5051436066 @default.
- W3048598321 creator A5058524655 @default.
- W3048598321 date "2020-09-28" @default.
- W3048598321 modified "2023-09-25" @default.
- W3048598321 title "Principles for clinical trials of coagulation factor IX products" @default.
- W3048598321 cites W1992233073 @default.
- W3048598321 cites W2007420660 @default.
- W3048598321 cites W2037201482 @default.
- W3048598321 cites W2159155672 @default.
- W3048598321 cites W2168251691 @default.
- W3048598321 doi "https://doi.org/10.34215/1609-1175-2020-3-11-18" @default.
- W3048598321 hasPublicationYear "2020" @default.
- W3048598321 type Work @default.
- W3048598321 sameAs 3048598321 @default.
- W3048598321 citedByCount "0" @default.
- W3048598321 crossrefType "journal-article" @default.
- W3048598321 hasAuthorship W3048598321A5023787037 @default.
- W3048598321 hasAuthorship W3048598321A5040970290 @default.
- W3048598321 hasAuthorship W3048598321A5051436066 @default.
- W3048598321 hasAuthorship W3048598321A5058524655 @default.
- W3048598321 hasBestOaLocation W30485983211 @default.
- W3048598321 hasConcept C126322002 @default.
- W3048598321 hasConcept C177713679 @default.
- W3048598321 hasConcept C2778382381 @default.
- W3048598321 hasConcept C2781221834 @default.
- W3048598321 hasConcept C535046627 @default.
- W3048598321 hasConcept C71924100 @default.
- W3048598321 hasConceptScore W3048598321C126322002 @default.
- W3048598321 hasConceptScore W3048598321C177713679 @default.
- W3048598321 hasConceptScore W3048598321C2778382381 @default.
- W3048598321 hasConceptScore W3048598321C2781221834 @default.
- W3048598321 hasConceptScore W3048598321C535046627 @default.
- W3048598321 hasConceptScore W3048598321C71924100 @default.
- W3048598321 hasLocation W30485983211 @default.
- W3048598321 hasOpenAccess W3048598321 @default.
- W3048598321 hasPrimaryLocation W30485983211 @default.
- W3048598321 hasRelatedWork W16951305 @default.
- W3048598321 hasRelatedWork W17317573 @default.
- W3048598321 hasRelatedWork W17966948 @default.
- W3048598321 hasRelatedWork W2053426 @default.
- W3048598321 hasRelatedWork W4584410 @default.
- W3048598321 hasRelatedWork W4733312 @default.
- W3048598321 hasRelatedWork W5780226 @default.
- W3048598321 hasRelatedWork W6178013 @default.
- W3048598321 hasRelatedWork W8576318 @default.
- W3048598321 hasRelatedWork W9635424 @default.
- W3048598321 isParatext "false" @default.
- W3048598321 isRetracted "false" @default.
- W3048598321 magId "3048598321" @default.
- W3048598321 workType "article" @default.