Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048602800> ?p ?o ?g. }
- W3048602800 abstract "Experimental studies have shown that infiltration of inflammatory cells as well as upregulation of some cytokines play a central role in the development of late effects of ionizing radiation in heart tissues. Evidences have shown that an increased level of TGF-β has a direct correlation with late effects of exposure to ionizing radiation such as chronic oxidative stress and fibrosis. Recent studies have shown that TGF-β, through upregulation of pro-oxidant enzymes such as NOX2 and NOX4, promotes continuous ROS production and accumulation of fibrosis.In present study, we aimed to evaluate the expression of NOX2 and NOX4 signaling pathways as well as possible modulatory effects of melatonin on the expression of these genes.In this experimental study, four groups of 20 rats (5 in each) were used as follows; G1: control; G2: melatonin; G3: radiation; G4: radiation + melatonin. 100 mg/kg of melatonin was administrated before irradiation of heart tissues with 15 Gy gamma rays. 10 weeks after irradiation, heart tissues were collected for real-time Polymerase chain reaction (PCR).Results showed a significant increase in the expression of TGF-β, Smad2, NF-kB, NOX2 and NOX4. The upregulation of NOX2 was more obvious by 20-fold compared to other genes. Except for TGF-β, melatonin could attenuate the expression of other genes.This study indicated that exposure of rat's heart tissues to radiation leads to upregulation of TGF-β-NOX4 and TGF-β-NOX2 pathways. Melatonin, through modulation of these genes, may be able to alleviate radiation-induced chronic oxidative stress and subsequent consequences." @default.
- W3048602800 created "2020-08-18" @default.
- W3048602800 creator A5001392317 @default.
- W3048602800 creator A5006809535 @default.
- W3048602800 creator A5016176244 @default.
- W3048602800 creator A5041093422 @default.
- W3048602800 creator A5070283845 @default.
- W3048602800 creator A5078987206 @default.
- W3048602800 creator A5086974824 @default.
- W3048602800 date "2021-01-01" @default.
- W3048602800 modified "2023-09-27" @default.
- W3048602800 title "Modulation of Radiation-Induced NADPH Oxidases in Rat’s Heart Tissues by Melatonin" @default.
- W3048602800 cites W1184238047 @default.
- W3048602800 cites W179432915 @default.
- W3048602800 cites W1973596985 @default.
- W3048602800 cites W1978478993 @default.
- W3048602800 cites W1979094235 @default.
- W3048602800 cites W1992028388 @default.
- W3048602800 cites W2004681594 @default.
- W3048602800 cites W2008090503 @default.
- W3048602800 cites W2009358874 @default.
- W3048602800 cites W2022437563 @default.
- W3048602800 cites W2027672676 @default.
- W3048602800 cites W2029654767 @default.
- W3048602800 cites W2071784200 @default.
- W3048602800 cites W2077560838 @default.
- W3048602800 cites W2082229480 @default.
- W3048602800 cites W2086360845 @default.
- W3048602800 cites W2101333302 @default.
- W3048602800 cites W2103868295 @default.
- W3048602800 cites W2104199379 @default.
- W3048602800 cites W2107793853 @default.
- W3048602800 cites W2124730679 @default.
- W3048602800 cites W2127303641 @default.
- W3048602800 cites W2128852700 @default.
- W3048602800 cites W2151118015 @default.
- W3048602800 cites W2167393995 @default.
- W3048602800 cites W2257942969 @default.
- W3048602800 cites W2436523721 @default.
- W3048602800 cites W2460646680 @default.
- W3048602800 cites W2530717372 @default.
- W3048602800 cites W2610819827 @default.
- W3048602800 cites W2757308637 @default.
- W3048602800 cites W2765344664 @default.
- W3048602800 cites W2768204036 @default.
- W3048602800 cites W2825477264 @default.
- W3048602800 cites W2885304537 @default.
- W3048602800 cites W2897498132 @default.
- W3048602800 cites W2962539274 @default.
- W3048602800 cites W2975172960 @default.
- W3048602800 cites W4236445721 @default.
- W3048602800 doi "https://doi.org/10.31661/jbpe.v0i0.1094" @default.
- W3048602800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8385219" @default.
- W3048602800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34458194" @default.
- W3048602800 hasPublicationYear "2021" @default.
- W3048602800 type Work @default.
- W3048602800 sameAs 3048602800 @default.
- W3048602800 citedByCount "1" @default.
- W3048602800 countsByYear W30486028002022 @default.
- W3048602800 crossrefType "journal-article" @default.
- W3048602800 hasAuthorship W3048602800A5001392317 @default.
- W3048602800 hasAuthorship W3048602800A5006809535 @default.
- W3048602800 hasAuthorship W3048602800A5016176244 @default.
- W3048602800 hasAuthorship W3048602800A5041093422 @default.
- W3048602800 hasAuthorship W3048602800A5070283845 @default.
- W3048602800 hasAuthorship W3048602800A5078987206 @default.
- W3048602800 hasAuthorship W3048602800A5086974824 @default.
- W3048602800 hasBestOaLocation W30486028001 @default.
- W3048602800 hasConcept C104317684 @default.
- W3048602800 hasConcept C118131993 @default.
- W3048602800 hasConcept C126322002 @default.
- W3048602800 hasConcept C127561419 @default.
- W3048602800 hasConcept C134018914 @default.
- W3048602800 hasConcept C185592680 @default.
- W3048602800 hasConcept C2775838275 @default.
- W3048602800 hasConcept C2776151105 @default.
- W3048602800 hasConcept C2778182776 @default.
- W3048602800 hasConcept C2779719074 @default.
- W3048602800 hasConcept C2779765511 @default.
- W3048602800 hasConcept C2780559512 @default.
- W3048602800 hasConcept C55493867 @default.
- W3048602800 hasConcept C71924100 @default.
- W3048602800 hasConcept C86803240 @default.
- W3048602800 hasConceptScore W3048602800C104317684 @default.
- W3048602800 hasConceptScore W3048602800C118131993 @default.
- W3048602800 hasConceptScore W3048602800C126322002 @default.
- W3048602800 hasConceptScore W3048602800C127561419 @default.
- W3048602800 hasConceptScore W3048602800C134018914 @default.
- W3048602800 hasConceptScore W3048602800C185592680 @default.
- W3048602800 hasConceptScore W3048602800C2775838275 @default.
- W3048602800 hasConceptScore W3048602800C2776151105 @default.
- W3048602800 hasConceptScore W3048602800C2778182776 @default.
- W3048602800 hasConceptScore W3048602800C2779719074 @default.
- W3048602800 hasConceptScore W3048602800C2779765511 @default.
- W3048602800 hasConceptScore W3048602800C2780559512 @default.
- W3048602800 hasConceptScore W3048602800C55493867 @default.
- W3048602800 hasConceptScore W3048602800C71924100 @default.
- W3048602800 hasConceptScore W3048602800C86803240 @default.
- W3048602800 hasLocation W30486028001 @default.
- W3048602800 hasLocation W30486028002 @default.