Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048604961> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3048604961 endingPage "5866" @default.
- W3048604961 startingPage "5861" @default.
- W3048604961 abstract "Butyrate, a product of dietary fiber, hyperactivates Wnt signaling in colorectal cancer (CRC) cells; this activity of butyrate is causally associated with the induction of apoptosis, and the repression of proliferation, in these cells. However, CRC can develop despite a high fiber diet; hence, butyrate resistance likely occurs during colonic neoplasia. To evaluate the mechanisms of butyrate resistance, HCT-116 CRC cells were previously made resistant to butyrate (HCT-R cell line); I observed that butyrate resistance in HCT-R cells is accompanied by repressed Wnt hyperactivation. CBP and p300 competitively bind to the Wnt signaling factor beta-catenin; CBP-Wnt activity is associated with proliferation, while p300-Wnt activity is associated with differentiation and apoptosis. While butyrate sensitive HCT-116 cells express p300, butyrate resistant HCT-R cells do not. Further, HCT-116 p300 knockout cells exhibit butyrate resistance, and restoration of p300 expression in these cells enhances butyrate sensitivity. Thus, p300 activity is a mediator of butyrate sensitivity in HCT-116-derived cell lines. In the present study, YH249, a pharmacological inhibitor of the p300-beta-catenin association, was utilized to more specifically evaluate the role of p300-Wnt signaling in butyrate responsiveness. Unexpectedly, YH249 potentiates butyrate-induced effects on apoptosis and cell proliferation in HCT-116 cells; in addition, potential off-target, p300-independent, effects of YH249 on butyrate-induced Wnt hyperactivation were observed. SW620 metastatic CRC cells express p300, but do not exhibit association of p300 with beta-catenin. Thus, I hypothesized that SW620 cells can be made butyrate resistant without loss of p300 expression, while butyrate resistance would still be associated with repressed Wnt hyperactivation; this hypothesis was confirmed. Thus, the data in toto suggest that while p300-Wnt activity is an important effector of butyrate sensitivity in some CRC cell lines, other, p300-independent pathways influencing butyrate sensitivity must also exist." @default.
- W3048604961 created "2020-08-18" @default.
- W3048604961 creator A5054453491 @default.
- W3048604961 date "2020-01-01" @default.
- W3048604961 modified "2023-10-15" @default.
- W3048604961 title "Further analysis of p300 in mediating effects of Butyrate in Colorectal Cancer Cells" @default.
- W3048604961 cites W1527381093 @default.
- W3048604961 cites W1973959916 @default.
- W3048604961 cites W1975881786 @default.
- W3048604961 cites W2077893873 @default.
- W3048604961 cites W2093423091 @default.
- W3048604961 cites W2115001053 @default.
- W3048604961 cites W2125436596 @default.
- W3048604961 cites W2138732842 @default.
- W3048604961 cites W2150359108 @default.
- W3048604961 cites W2757099799 @default.
- W3048604961 doi "https://doi.org/10.7150/jca.47160" @default.
- W3048604961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7477411" @default.
- W3048604961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32922528" @default.
- W3048604961 hasPublicationYear "2020" @default.
- W3048604961 type Work @default.
- W3048604961 sameAs 3048604961 @default.
- W3048604961 citedByCount "4" @default.
- W3048604961 countsByYear W30486049612022 @default.
- W3048604961 countsByYear W30486049612023 @default.
- W3048604961 crossrefType "journal-article" @default.
- W3048604961 hasAuthorship W3048604961A5054453491 @default.
- W3048604961 hasBestOaLocation W30486049611 @default.
- W3048604961 hasConcept C100544194 @default.
- W3048604961 hasConcept C121608353 @default.
- W3048604961 hasConcept C126322002 @default.
- W3048604961 hasConcept C137620995 @default.
- W3048604961 hasConcept C185592680 @default.
- W3048604961 hasConcept C190283241 @default.
- W3048604961 hasConcept C2776979534 @default.
- W3048604961 hasConcept C2778366672 @default.
- W3048604961 hasConcept C502942594 @default.
- W3048604961 hasConcept C526805850 @default.
- W3048604961 hasConcept C54355233 @default.
- W3048604961 hasConcept C55493867 @default.
- W3048604961 hasConcept C62112901 @default.
- W3048604961 hasConcept C62478195 @default.
- W3048604961 hasConcept C71924100 @default.
- W3048604961 hasConcept C81885089 @default.
- W3048604961 hasConcept C86803240 @default.
- W3048604961 hasConcept C95444343 @default.
- W3048604961 hasConceptScore W3048604961C100544194 @default.
- W3048604961 hasConceptScore W3048604961C121608353 @default.
- W3048604961 hasConceptScore W3048604961C126322002 @default.
- W3048604961 hasConceptScore W3048604961C137620995 @default.
- W3048604961 hasConceptScore W3048604961C185592680 @default.
- W3048604961 hasConceptScore W3048604961C190283241 @default.
- W3048604961 hasConceptScore W3048604961C2776979534 @default.
- W3048604961 hasConceptScore W3048604961C2778366672 @default.
- W3048604961 hasConceptScore W3048604961C502942594 @default.
- W3048604961 hasConceptScore W3048604961C526805850 @default.
- W3048604961 hasConceptScore W3048604961C54355233 @default.
- W3048604961 hasConceptScore W3048604961C55493867 @default.
- W3048604961 hasConceptScore W3048604961C62112901 @default.
- W3048604961 hasConceptScore W3048604961C62478195 @default.
- W3048604961 hasConceptScore W3048604961C71924100 @default.
- W3048604961 hasConceptScore W3048604961C81885089 @default.
- W3048604961 hasConceptScore W3048604961C86803240 @default.
- W3048604961 hasConceptScore W3048604961C95444343 @default.
- W3048604961 hasIssue "20" @default.
- W3048604961 hasLocation W30486049611 @default.
- W3048604961 hasLocation W30486049612 @default.
- W3048604961 hasLocation W30486049613 @default.
- W3048604961 hasOpenAccess W3048604961 @default.
- W3048604961 hasPrimaryLocation W30486049611 @default.
- W3048604961 hasRelatedWork W131911175 @default.
- W3048604961 hasRelatedWork W1498211168 @default.
- W3048604961 hasRelatedWork W155520342 @default.
- W3048604961 hasRelatedWork W1996703972 @default.
- W3048604961 hasRelatedWork W2003391295 @default.
- W3048604961 hasRelatedWork W2143053411 @default.
- W3048604961 hasRelatedWork W2147858742 @default.
- W3048604961 hasRelatedWork W2157744295 @default.
- W3048604961 hasRelatedWork W2349120687 @default.
- W3048604961 hasRelatedWork W2888606631 @default.
- W3048604961 hasVolume "11" @default.
- W3048604961 isParatext "false" @default.
- W3048604961 isRetracted "false" @default.
- W3048604961 magId "3048604961" @default.
- W3048604961 workType "article" @default.