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• W3048607891 endingPage "129" @default.
• W3048607891 startingPage "129" @default.
• W3048607891 abstract "Ischemic brain injury causes neuronal death and inflammation. Inflammation activates protein-tyrosine phosphatase 1B (PTP1B). Here, we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke: by photothrombosis, focal ischemic lesions were induced in the sensorimotor cortex (SM stroke) or in the peri-prefrontal cortex (peri-PFC stroke). Elevated PTP1B expression was detected at 4 days and up to 6 weeks after stroke. While ablation of PTP1B in neurons of neuronal knockout (NKO) mice had no effect on the volume or resorption of ischemic lesions, markedly different effects on functional recovery were observed. SM stroke caused severe sensory and motor deficits (adhesive removal test) in wild type and NKO mice at 4 days, but NKO mice showed drastically improved sensory and motor functional recovery at 8 days. In addition, peri-PFC stroke caused anxiety-like behaviors (elevated plus maze and open field tests), and depression-like behaviors (forced swimming and tail suspension tests) in wild type mice 9 and 28 days after stroke, respectively, with minimal effect on sensory and motor function. Peri-PFC stroke-induced affective disorders were associated with fewer active (FosB+) neurons in the PFC and nucleus accumbens but more FosB+ neurons in the basolateral amygdala, compared to sham-operated mice. In contrast, mice with neuronal ablation of PTP1B were protected from anxiety-like and depression-like behaviors and showed no change in FosB+ neurons after peri-PFC stroke. Taken together, our study identifies neuronal PTP1B as a key component that hinders sensory and motor functional recovery and also contributes to the development of anxiety-like and depression-like behaviors after stroke. Thus, PTP1B may represent a novel therapeutic target to improve stroke recovery. All procedures for animal use were approved by the Animal Care and Use Committee of the University of Ottawa Animal Care and Veterinary Service (protocol 1806) on July 27, 2018." @default.
• W3048607891 created "2020-08-18" @default.
• W3048607891 creator A5001575849 @default.
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• W3048607891 creator A5025846764 @default.
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• W3048607891 creator A5074923441 @default.
• W3048607891 date "2021-01-01" @default.
• W3048607891 modified "2023-10-17" @default.
• W3048607891 title "Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models" @default.
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• W3048607891 doi "https://doi.org/10.4103/1673-5374.286970" @default.
• W3048607891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7818877" @default.
• W3048607891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32788467" @default.
• W3048607891 hasPublicationYear "2021" @default.

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