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- W3048607982 abstract "Plastic polymers have quickly become one of the most abundant materials on Earth due to their low production cost and high versatility. Unfortunately, some of the discarded plastic can make its way into the environment and become fragmented into smaller microscopic particles, termed secondary microplastics (MP). In addition, primary MP, purposely manufactured microscopic plastic particles, can also make their way into our environment via various routes. Owing to their size and resilience, these MP can then be easily ingested by living organisms. The effect of MP particles on living organisms is suspected to have negative implications, especially during early development. In this study, we examined the effects of polyethylene MP ingestion for four and ten days of exposure starting at 5 days post-fertilization (dpf). In particular, we examined the effects of polyethylene MP exposure on resting metabolic rate, on gene expression of several inflammatory and oxidative stress linked genes, and on microbiome composition between treatments. Overall, we found no evidence of broad metabolic disturbances or inflammatory markers in MP-exposed fish for either period of time. However, there was a significant increase in the oxidative stress mediator L-FABP that occurred at 15 dpf. Furthermore, the microbiome was disrupted by MP exposure, with evidence of an increased abundance of Bacteroidetes in MP fish, a combination frequently found in intestinal pathologies. Thus, it appears that acute polyethylene MP exposure can increase oxidative stress and dysbiosis, which may render the animal more susceptible to diseases." @default.
- W3048607982 created "2020-08-18" @default.
- W3048607982 creator A5017810486 @default.
- W3048607982 creator A5056689250 @default.
- W3048607982 creator A5057082782 @default.
- W3048607982 creator A5059789817 @default.
- W3048607982 creator A5077278637 @default.
- W3048607982 date "2020-08-11" @default.
- W3048607982 modified "2023-09-25" @default.
- W3048607982 title "Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish" @default.
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