Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048635192> ?p ?o ?g. }
- W3048635192 endingPage "45" @default.
- W3048635192 startingPage "1" @default.
- W3048635192 abstract "Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine, relying principally on their differentiation/regeneration potential, immunomodulatory properties, paracrine effects, and potent homing ability with minimal if any ethical concerns. Even though multiple preclinical and clinical studies have demonstrated remarkable properties for MSCs, the clinical applicability of MSC-based therapies is still questionable. Several challenges exist that critically hinder a successful clinical translation of MSC-based therapies, including but not limited to heterogeneity of their populations, variability in their quality and quantity, donor-related factors, discrepancies in protocols for isolation, in vitro expansion and premodification, and variability in methods of cell delivery, dosing, and cell homing. Alterations of MSC viability, proliferation, properties, and/or function are also affected by various drugs and chemicals. Moreover, significant safety concerns exist due to possible teratogenic/neoplastic potential and transmission of infectious diseases. Through the current review, we aim to highlight the major challenges facing MSCs’ human clinical translation and shed light on the undergoing strategies to overcome them." @default.
- W3048635192 created "2020-08-18" @default.
- W3048635192 creator A5018935463 @default.
- W3048635192 creator A5025369432 @default.
- W3048635192 creator A5038898499 @default.
- W3048635192 creator A5053204953 @default.
- W3048635192 creator A5061388128 @default.
- W3048635192 creator A5062754262 @default.
- W3048635192 creator A5066691031 @default.
- W3048635192 date "2020-08-11" @default.
- W3048635192 modified "2023-10-02" @default.
- W3048635192 title "Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation" @default.
- W3048635192 cites W1131739878 @default.
- W3048635192 cites W122755776 @default.
- W3048635192 cites W1480124154 @default.
- W3048635192 cites W1485875137 @default.
- W3048635192 cites W1489656214 @default.
- W3048635192 cites W1508798545 @default.
- W3048635192 cites W1514803062 @default.
- W3048635192 cites W1527969433 @default.
- W3048635192 cites W1529792189 @default.
- W3048635192 cites W1548475599 @default.
- W3048635192 cites W1550630139 @default.
- W3048635192 cites W1560977520 @default.
- W3048635192 cites W1564282316 @default.
- W3048635192 cites W1568003817 @default.
- W3048635192 cites W1604731715 @default.
- W3048635192 cites W1607471435 @default.
- W3048635192 cites W1678817836 @default.
- W3048635192 cites W1708123803 @default.
- W3048635192 cites W1779654418 @default.
- W3048635192 cites W1830000322 @default.
- W3048635192 cites W183877133 @default.
- W3048635192 cites W1885628926 @default.
- W3048635192 cites W1902212602 @default.
- W3048635192 cites W1910243310 @default.
- W3048635192 cites W1950417800 @default.
- W3048635192 cites W1965975485 @default.
- W3048635192 cites W1966292190 @default.
- W3048635192 cites W1966689494 @default.
- W3048635192 cites W1967217261 @default.
- W3048635192 cites W1967966539 @default.
- W3048635192 cites W1968102151 @default.
- W3048635192 cites W1969108266 @default.
- W3048635192 cites W1969166539 @default.
- W3048635192 cites W1969583812 @default.
- W3048635192 cites W1969840060 @default.
- W3048635192 cites W1970247562 @default.
- W3048635192 cites W1970404807 @default.
- W3048635192 cites W1970692199 @default.
- W3048635192 cites W1971218073 @default.
- W3048635192 cites W1971629816 @default.
- W3048635192 cites W1974394551 @default.
- W3048635192 cites W1975564296 @default.
- W3048635192 cites W1975833234 @default.
- W3048635192 cites W1975880740 @default.
- W3048635192 cites W1976065936 @default.
- W3048635192 cites W1976501240 @default.
- W3048635192 cites W1976675965 @default.
- W3048635192 cites W1980574315 @default.
- W3048635192 cites W1980776838 @default.
- W3048635192 cites W1981131778 @default.
- W3048635192 cites W1981222696 @default.
- W3048635192 cites W1981724886 @default.
- W3048635192 cites W1981922215 @default.
- W3048635192 cites W1982313967 @default.
- W3048635192 cites W1983021704 @default.
- W3048635192 cites W1984058266 @default.
- W3048635192 cites W1984180661 @default.
- W3048635192 cites W1984702561 @default.
- W3048635192 cites W1985048736 @default.
- W3048635192 cites W1986392290 @default.
- W3048635192 cites W1986543208 @default.
- W3048635192 cites W1986960611 @default.
- W3048635192 cites W1987396076 @default.
- W3048635192 cites W1988509972 @default.
- W3048635192 cites W1988634174 @default.
- W3048635192 cites W1988680604 @default.
- W3048635192 cites W1990226567 @default.
- W3048635192 cites W1990357530 @default.
- W3048635192 cites W1990477570 @default.
- W3048635192 cites W1990615197 @default.
- W3048635192 cites W1990665335 @default.
- W3048635192 cites W1991288680 @default.
- W3048635192 cites W1991415492 @default.
- W3048635192 cites W1991790903 @default.
- W3048635192 cites W1992519397 @default.
- W3048635192 cites W1992935708 @default.
- W3048635192 cites W1993816334 @default.
- W3048635192 cites W1993949177 @default.
- W3048635192 cites W1994117751 @default.
- W3048635192 cites W1994923567 @default.
- W3048635192 cites W1995281971 @default.
- W3048635192 cites W1996773781 @default.
- W3048635192 cites W1996789930 @default.
- W3048635192 cites W1996993164 @default.
- W3048635192 cites W1997665437 @default.
- W3048635192 cites W1998040484 @default.