FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048636908> ?p ?o ?g. }

• W3048636908 abstract "If the kidney suddenly loses its ability to remove waste, acute kidney injury (AKI) will occur that dangerous levels of waste may accumulate, and the chemical composition of the blood may become unbalanced. AKI usually develops rapidly within a few days and is very common in hospitalized patients, especially those in urgent need of intensive care. AKI can be fatal and requires serious treatment. However, it can be reversible. The purpose of this research was to investigate the effects of recombinant human erythropoietin (rhEPO) on the expression of nuclear factor E2-related factor 2 (Nuclear factor E2, Nrf2) and Heme oxygenase (HO-1) in rats AKI and its protective effects on the kidney. For this purpose, 40 SD rats were averagely and randomly divided into 4 groups: control group, sham operation group, model group, and rhEPO group. The rhEPO group was injected with 5% glucose mixed with rhEPO to form 3000 IU/ (kg/d) rhEPO. Except for the rhEPO group, three groups were injected with 5% glucose at the same dose level as the rhEPO group respectively. Before the third administration, the renal pedicle was clamped for 60 min and then perfused for 24 hours. Changes of Serum creatinine (Scr) and Urea nitrogen (BUN) of rats in each group were detected before and after modeling. Twenty-four hours after modeling, renal tissues of rats in each group were taken, and expressions of Nrf2 and HO-1 in renal tissues were detected by qRT-PCR and Western blot methods. There were no significant differences in Scr and BUN contents in the four groups before modeling (p> 0.05). There were no significant differences in Scr and BUN contents in the control group and sham operation group after modeling compared with those before modeling (p> 0.05). Expressions of Nrf2 and HO-1 in the rhEPO group were higher than those in the model group, the sham operation group and the control group (p 0.05). rhEPO can induce expressions of Nrf2 and HO-1 in AKI rats. RhEPO has a protective effect on the kidney, which may be related to expressions of Nrf2 and HO-1." @default.
• W3048636908 created "2020-08-18" @default.
• W3048636908 creator A5010734985 @default.
• W3048636908 creator A5020891614 @default.
• W3048636908 creator A5022703808 @default.
• W3048636908 creator A5060659642 @default.
• W3048636908 creator A5080740258 @default.
• W3048636908 date "2020-07-31" @default.
• W3048636908 modified "2023-09-24" @default.
• W3048636908 title "Effects of rhEPO on Nrf2 and HO-1 expression in rats with acute kidney injury and its protective effects on kidney" @default.
• W3048636908 cites W1597980115 @default.
• W3048636908 cites W1754042278 @default.
• W3048636908 cites W1989541636 @default.
• W3048636908 cites W2008785905 @default.
• W3048636908 cites W2012809923 @default.
• W3048636908 cites W2019690943 @default.
• W3048636908 cites W2043310310 @default.
• W3048636908 cites W2047860374 @default.
• W3048636908 cites W2080664816 @default.
• W3048636908 cites W2125394545 @default.
• W3048636908 cites W2141559993 @default.
• W3048636908 cites W2147375079 @default.
• W3048636908 cites W2150532545 @default.
• W3048636908 cites W2231224028 @default.
• W3048636908 cites W2284399267 @default.
• W3048636908 cites W2344169552 @default.
• W3048636908 cites W2405898853 @default.
• W3048636908 cites W2509434666 @default.
• W3048636908 cites W2516277878 @default.
• W3048636908 cites W2565791443 @default.
• W3048636908 cites W2581431829 @default.
• W3048636908 cites W2587912615 @default.
• W3048636908 cites W2746379258 @default.
• W3048636908 cites W2753475483 @default.
• W3048636908 cites W2767636640 @default.
• W3048636908 cites W2768405172 @default.
• W3048636908 cites W2779563463 @default.
• W3048636908 cites W2790532714 @default.
• W3048636908 cites W2801177589 @default.
• W3048636908 cites W2897783599 @default.
• W3048636908 cites W2899077686 @default.
• W3048636908 cites W2902268243 @default.
• W3048636908 cites W2905881221 @default.
• W3048636908 cites W2907663273 @default.
• W3048636908 cites W2917270873 @default.
• W3048636908 cites W2921884745 @default.
• W3048636908 cites W2961556276 @default.
• W3048636908 cites W2965172271 @default.
• W3048636908 cites W2999135278 @default.
• W3048636908 cites W3007736933 @default.
• W3048636908 cites W3014810656 @default.
• W3048636908 cites W3017218371 @default.
• W3048636908 cites W3024518137 @default.
• W3048636908 cites W3104467567 @default.
• W3048636908 cites W856782317 @default.
• W3048636908 doi "https://doi.org/10.14715/cmb/2020.66.5.15" @default.
• W3048636908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33040818" @default.
• W3048636908 hasPublicationYear "2020" @default.
• W3048636908 type Work @default.
• W3048636908 sameAs 3048636908 @default.
• W3048636908 citedByCount "0" @default.
• W3048636908 crossrefType "journal-article" @default.
• W3048636908 hasAuthorship W3048636908A5010734985 @default.
• W3048636908 hasAuthorship W3048636908A5020891614 @default.
• W3048636908 hasAuthorship W3048636908A5022703808 @default.
• W3048636908 hasAuthorship W3048636908A5060659642 @default.
• W3048636908 hasAuthorship W3048636908A5080740258 @default.
• W3048636908 hasConcept C126322002 @default.
• W3048636908 hasConcept C126894567 @default.
• W3048636908 hasConcept C134018914 @default.
• W3048636908 hasConcept C181199279 @default.
• W3048636908 hasConcept C185592680 @default.
• W3048636908 hasConcept C2776217839 @default.
• W3048636908 hasConcept C2778176769 @default.
• W3048636908 hasConcept C2778534260 @default.
• W3048636908 hasConcept C2779219270 @default.
• W3048636908 hasConcept C2780091579 @default.
• W3048636908 hasConcept C2780306776 @default.
• W3048636908 hasConcept C2780472472 @default.
• W3048636908 hasConcept C55493867 @default.
• W3048636908 hasConcept C71924100 @default.
• W3048636908 hasConcept C98274493 @default.
• W3048636908 hasConceptScore W3048636908C126322002 @default.
• W3048636908 hasConceptScore W3048636908C126894567 @default.
• W3048636908 hasConceptScore W3048636908C134018914 @default.
• W3048636908 hasConceptScore W3048636908C181199279 @default.
• W3048636908 hasConceptScore W3048636908C185592680 @default.
• W3048636908 hasConceptScore W3048636908C2776217839 @default.
• W3048636908 hasConceptScore W3048636908C2778176769 @default.
• W3048636908 hasConceptScore W3048636908C2778534260 @default.
• W3048636908 hasConceptScore W3048636908C2779219270 @default.
• W3048636908 hasConceptScore W3048636908C2780091579 @default.
• W3048636908 hasConceptScore W3048636908C2780306776 @default.
• W3048636908 hasConceptScore W3048636908C2780472472 @default.
• W3048636908 hasConceptScore W3048636908C55493867 @default.
• W3048636908 hasConceptScore W3048636908C71924100 @default.
• W3048636908 hasConceptScore W3048636908C98274493 @default.
• W3048636908 hasLocation W30486369081 @default.
• W3048636908 hasOpenAccess W3048636908 @default.
• W3048636908 hasPrimaryLocation W30486369081 @default.

• next