Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048637028> ?p ?o ?g. }
- W3048637028 endingPage "20688" @default.
- W3048637028 startingPage "20681" @default.
- W3048637028 abstract "Significance Cancer evolution cannot be observed directly in patients, and new methodologies are needed for obtaining a quantitative understanding of this obscure process. We develop and analyze a stochastic model of malignant transformation in the colon that precisely quantifies the process of colorectal carcinogenesis in patients through loss of tumor suppressors APC and TP53 and gain of the KRAS oncogene. Our study employs experimentally measured mutation rates in the colon and growth advantages provided by driver mutations. We calculate the probability of a colorectal malignancy, the sizes of premalignant lesions, and the order of acquisition of driver mutations during colorectal tumor evolution. Our model can be used as a starting point in evaluating early detection and treatment efforts." @default.
- W3048637028 created "2020-08-18" @default.
- W3048637028 creator A5001277069 @default.
- W3048637028 creator A5053304093 @default.
- W3048637028 creator A5062248785 @default.
- W3048637028 date "2020-08-11" @default.
- W3048637028 modified "2023-10-17" @default.
- W3048637028 title "Mathematical model of colorectal cancer initiation" @default.
- W3048637028 cites W1908327267 @default.
- W3048637028 cites W1964154017 @default.
- W3048637028 cites W1965766641 @default.
- W3048637028 cites W1968407767 @default.
- W3048637028 cites W1968969468 @default.
- W3048637028 cites W1985091316 @default.
- W3048637028 cites W1999403469 @default.
- W3048637028 cites W2001258296 @default.
- W3048637028 cites W2008227339 @default.
- W3048637028 cites W2011912935 @default.
- W3048637028 cites W2019078072 @default.
- W3048637028 cites W2034509811 @default.
- W3048637028 cites W2036831253 @default.
- W3048637028 cites W2043635051 @default.
- W3048637028 cites W2044433401 @default.
- W3048637028 cites W2057030383 @default.
- W3048637028 cites W2073294762 @default.
- W3048637028 cites W2077098920 @default.
- W3048637028 cites W2077858999 @default.
- W3048637028 cites W2088245621 @default.
- W3048637028 cites W2091723114 @default.
- W3048637028 cites W2101354849 @default.
- W3048637028 cites W2101898337 @default.
- W3048637028 cites W2104824960 @default.
- W3048637028 cites W2105986617 @default.
- W3048637028 cites W2114031931 @default.
- W3048637028 cites W2124581351 @default.
- W3048637028 cites W2127218675 @default.
- W3048637028 cites W2136272158 @default.
- W3048637028 cites W2148300747 @default.
- W3048637028 cites W2150520316 @default.
- W3048637028 cites W2150625137 @default.
- W3048637028 cites W2152506548 @default.
- W3048637028 cites W2153618863 @default.
- W3048637028 cites W2154225779 @default.
- W3048637028 cites W2160759097 @default.
- W3048637028 cites W2162756888 @default.
- W3048637028 cites W2210259689 @default.
- W3048637028 cites W2262414037 @default.
- W3048637028 cites W2416156938 @default.
- W3048637028 cites W2466880911 @default.
- W3048637028 cites W2524881570 @default.
- W3048637028 cites W2561919886 @default.
- W3048637028 cites W2604024577 @default.
- W3048637028 cites W2691929059 @default.
- W3048637028 cites W2785187242 @default.
- W3048637028 cites W2798041799 @default.
- W3048637028 cites W2804079254 @default.
- W3048637028 cites W2907147479 @default.
- W3048637028 cites W2942952616 @default.
- W3048637028 cites W2947209894 @default.
- W3048637028 cites W2969694562 @default.
- W3048637028 cites W2981552021 @default.
- W3048637028 cites W2989956209 @default.
- W3048637028 cites W3004647847 @default.
- W3048637028 cites W3004856249 @default.
- W3048637028 cites W4248142848 @default.
- W3048637028 doi "https://doi.org/10.1073/pnas.2003771117" @default.
- W3048637028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7456111" @default.
- W3048637028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32788368" @default.
- W3048637028 hasPublicationYear "2020" @default.
- W3048637028 type Work @default.
- W3048637028 sameAs 3048637028 @default.
- W3048637028 citedByCount "37" @default.
- W3048637028 countsByYear W30486370282020 @default.
- W3048637028 countsByYear W30486370282021 @default.
- W3048637028 countsByYear W30486370282022 @default.
- W3048637028 countsByYear W30486370282023 @default.
- W3048637028 crossrefType "journal-article" @default.
- W3048637028 hasAuthorship W3048637028A5001277069 @default.
- W3048637028 hasAuthorship W3048637028A5053304093 @default.
- W3048637028 hasAuthorship W3048637028A5062248785 @default.
- W3048637028 hasBestOaLocation W30486370281 @default.
- W3048637028 hasConcept C104317684 @default.
- W3048637028 hasConcept C121608353 @default.
- W3048637028 hasConcept C126322002 @default.
- W3048637028 hasConcept C143998085 @default.
- W3048637028 hasConcept C176944494 @default.
- W3048637028 hasConcept C2779399171 @default.
- W3048637028 hasConcept C2781018059 @default.
- W3048637028 hasConcept C2781187634 @default.
- W3048637028 hasConcept C29537977 @default.
- W3048637028 hasConcept C31033888 @default.
- W3048637028 hasConcept C501734568 @default.
- W3048637028 hasConcept C502942594 @default.
- W3048637028 hasConcept C526805850 @default.
- W3048637028 hasConcept C54355233 @default.
- W3048637028 hasConcept C555283112 @default.
- W3048637028 hasConcept C71924100 @default.
- W3048637028 hasConcept C86803240 @default.