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- W3048642618 abstract "RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here, we examine the functions of RNA modifications, with a focus on N6-methyladenosine (m6A), in hematopoietic stem cells under normal conditions and in malignancy. The m6A RNA modification is a critical regulator of hematopoiesis. Disruption of different elements of the m6A machinery can skew the balance of self-renewal and differentiation in normal hematopoietic stem cells. The m6A reader, writer, and eraser proteins are also overexpressed in myeloid leukemia, and disruption of their function impairs leukemogenesis. RNA m6A modification governs important aspects of immune system function, including immune cell development, immune signaling, and recognition of RNA as foreign or self. In hematopoietic stem cells, endogenously derived double-stranded RNA can form in the absence of m6A, inducing deleterious inflammatory pathways which compromise stem cell function. The RNA modification m6A exerts a variety of functions in normal hematopoietic stem cells as well as leukemic cells. Pharmacologic modulation of different elements of the m6A machinery provides a promising avenue for ex vivo expansion of hematopoietic stem cells in the transplant setting, as well as for leukemia therapy." @default.
- W3048642618 created "2020-08-18" @default.
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- W3048642618 date "2020-08-12" @default.
- W3048642618 modified "2023-10-08" @default.
- W3048642618 title "The Role of RNA Epigenetic Modification in Normal and Malignant Hematopoiesis" @default.
- W3048642618 cites W1895681508 @default.
- W3048642618 cites W1941339056 @default.
- W3048642618 cites W1981629946 @default.
- W3048642618 cites W1991807334 @default.
- W3048642618 cites W1995675594 @default.
- W3048642618 cites W2002458471 @default.
- W3048642618 cites W2007429249 @default.
- W3048642618 cites W2016135634 @default.
- W3048642618 cites W2025980739 @default.
- W3048642618 cites W2041328373 @default.
- W3048642618 cites W2045281368 @default.
- W3048642618 cites W2059439438 @default.
- W3048642618 cites W2065847836 @default.
- W3048642618 cites W2078964320 @default.
- W3048642618 cites W2078972833 @default.
- W3048642618 cites W2080452140 @default.
- W3048642618 cites W2085106808 @default.
- W3048642618 cites W2116445953 @default.
- W3048642618 cites W2127738065 @default.
- W3048642618 cites W2134061682 @default.
- W3048642618 cites W2154313451 @default.
- W3048642618 cites W2156891661 @default.
- W3048642618 cites W2165547003 @default.
- W3048642618 cites W2171577249 @default.
- W3048642618 cites W2175514210 @default.
- W3048642618 cites W2269054226 @default.
- W3048642618 cites W2509465044 @default.
- W3048642618 cites W2516993644 @default.
- W3048642618 cites W2522303658 @default.
- W3048642618 cites W2562211106 @default.
- W3048642618 cites W2563912688 @default.
- W3048642618 cites W2575691519 @default.
- W3048642618 cites W2578506026 @default.
- W3048642618 cites W2580082637 @default.
- W3048642618 cites W2584920615 @default.
- W3048642618 cites W2592988313 @default.
- W3048642618 cites W2608560932 @default.
- W3048642618 cites W2616848081 @default.
- W3048642618 cites W2624533108 @default.
- W3048642618 cites W2627064270 @default.
- W3048642618 cites W2632544498 @default.
- W3048642618 cites W2690599584 @default.
- W3048642618 cites W2743522323 @default.
- W3048642618 cites W2749219966 @default.
- W3048642618 cites W2751668414 @default.
- W3048642618 cites W2754499625 @default.
- W3048642618 cites W2769630486 @default.
- W3048642618 cites W2772792536 @default.
- W3048642618 cites W2773525744 @default.
- W3048642618 cites W2776540408 @default.
- W3048642618 cites W2781532633 @default.
- W3048642618 cites W2784757192 @default.
- W3048642618 cites W2793785833 @default.
- W3048642618 cites W2795813366 @default.
- W3048642618 cites W2883478231 @default.
- W3048642618 cites W2884688483 @default.
- W3048642618 cites W2885965305 @default.
- W3048642618 cites W2887723888 @default.
- W3048642618 cites W2889358492 @default.
- W3048642618 cites W2889993050 @default.
- W3048642618 cites W2901594129 @default.
- W3048642618 cites W2903232633 @default.
- W3048642618 cites W2904139947 @default.
- W3048642618 cites W2915489297 @default.
- W3048642618 cites W2921763102 @default.
- W3048642618 cites W2941121518 @default.
- W3048642618 cites W2941333182 @default.
- W3048642618 cites W2942816224 @default.
- W3048642618 cites W2959403793 @default.
- W3048642618 cites W2962780260 @default.
- W3048642618 cites W2967414383 @default.
- W3048642618 cites W2969469813 @default.
- W3048642618 cites W2970224263 @default.
- W3048642618 cites W2972933339 @default.
- W3048642618 cites W2994940889 @default.
- W3048642618 cites W2999012956 @default.
- W3048642618 cites W3004326018 @default.
- W3048642618 cites W3015190397 @default.
- W3048642618 cites W3024244355 @default.
- W3048642618 cites W3025043200 @default.
- W3048642618 cites W3026033619 @default.
- W3048642618 cites W3033445573 @default.
- W3048642618 doi "https://doi.org/10.1007/s40778-020-00178-y" @default.
- W3048642618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7992056" @default.
- W3048642618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33777659" @default.
- W3048642618 hasPublicationYear "2020" @default.
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