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- W3048644433 abstract "Background Connexins are membrane channel forming proteins that are critically involved in different aspects of vascular physiology and pathology. Connexins have a role in the systemic vasculature in mediating vasoreactivity and tissue morphology through direct cell to cell contact. Here, we assess the role of connexin 43 (Cx43) in vasoreactivity of the male and female mouse aortae using both genetic knockdown and pharmacological inhibiton of Cx43. Materials and Methods Thoracic aorta was dissected free from male and female wild-type (WT) and connexin 43 heterozygous (Cx43+/−) littermate mice (C57BL/6 background, 4 to 7 months old). Wire myography was used to construct concentration-response curves (CRCs) to the thromboxane A2 (TP) receptor agonist U46619 (0.1 nM -10 µM), and to acetylcholine (ACh) (0.1 nM 30 µM), in the presence and absence of 37,43Gap27 (100 µM; an inhibitor of Cx37 and Cx43). Results U46619 was more potent in male and female Cx43+/− mice compared to WT mice (n=6, p Conclusion Cx43 plays a role in vasoreactivity of the mouse aorta." @default.
- W3048644433 created "2020-08-18" @default.
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- W3048644433 date "2020-04-01" @default.
- W3048644433 modified "2023-09-27" @default.
- W3048644433 title "P5 The role of connexin 43 in aortic vasoreactivity in mice" @default.
- W3048644433 doi "https://doi.org/10.1136/heartjnl-2020-scf.15" @default.
- W3048644433 hasPublicationYear "2020" @default.
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