Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048647521> ?p ?o ?g. }
- W3048647521 abstract "Abstract Thrombosis is a life‐threatening pathological condition in which blood clots form in blood vessels, obstructing or interfering with blood flow. Thrombolytic agents (TAs) are enzymes that can catalyze the conversion of plasminogen to plasmin to dissolve blood clots. The plasmin formed by TAs breaks down fibrin clots into soluble fibrin that finally dissolves thrombi. Several TAs have been developed to treat various thromboembolic diseases, such as pulmonary embolisms, acute myocardial infarction, deep vein thrombosis, and extensive coronary emboli. However, systemic TA administration can trigger non‐specific activation that can increase the incidence of bleeding. Moreover, protein‐based TAs are rapidly inactivated upon injection resulting in the need for large doses. To overcome these limitations, various types of nanocarriers have been introduced that enhance the pharmacokinetic effects by protecting the TA from the biological environment and targeting the release into coagulation. The nanocarriers show increasing half‐life, reducing side effects, and improving overall TA efficacy. In this work, the recent advances in various types of TAs and nanocarriers are thoroughly reviewed. Various types of nanocarriers, including lipid‐based, polymer‐based, and metal‐based nanoparticles are described, for the targeted delivery of TAs. This work also provides insights into issues related to the future of TA development and successful clinical translation." @default.
- W3048647521 created "2020-08-18" @default.
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- W3048647521 date "2020-08-12" @default.
- W3048647521 modified "2023-10-16" @default.
- W3048647521 title "Thrombolytic Agents: Nanocarriers in Controlled Release" @default.
- W3048647521 cites W1026976829 @default.
- W3048647521 cites W1481234838 @default.
- W3048647521 cites W1489530459 @default.
- W3048647521 cites W1527458440 @default.
- W3048647521 cites W1607637205 @default.
- W3048647521 cites W1877301297 @default.
- W3048647521 cites W1963797031 @default.
- W3048647521 cites W1964458201 @default.
- W3048647521 cites W1966250539 @default.
- W3048647521 cites W1967986243 @default.
- W3048647521 cites W1970532400 @default.
- W3048647521 cites W1971971998 @default.
- W3048647521 cites W1973809917 @default.
- W3048647521 cites W1975337498 @default.
- W3048647521 cites W1975809262 @default.
- W3048647521 cites W1977889525 @default.
- W3048647521 cites W1981415010 @default.
- W3048647521 cites W1982407363 @default.
- W3048647521 cites W1984256156 @default.
- W3048647521 cites W1984676621 @default.
- W3048647521 cites W1989567618 @default.
- W3048647521 cites W1991550524 @default.
- W3048647521 cites W1993785397 @default.
- W3048647521 cites W1994207065 @default.
- W3048647521 cites W1994936258 @default.
- W3048647521 cites W1997263832 @default.
- W3048647521 cites W2004509825 @default.
- W3048647521 cites W2004791516 @default.
- W3048647521 cites W2007868399 @default.
- W3048647521 cites W2008920531 @default.
- W3048647521 cites W2008984449 @default.
- W3048647521 cites W2011804459 @default.
- W3048647521 cites W2012189236 @default.
- W3048647521 cites W2015461951 @default.
- W3048647521 cites W2021465434 @default.
- W3048647521 cites W2021915803 @default.
- W3048647521 cites W2022609772 @default.
- W3048647521 cites W2024773717 @default.
- W3048647521 cites W2025653778 @default.
- W3048647521 cites W2027179732 @default.
- W3048647521 cites W2029091816 @default.
- W3048647521 cites W2037638904 @default.
- W3048647521 cites W2038275338 @default.
- W3048647521 cites W2039333258 @default.
- W3048647521 cites W2039821207 @default.
- W3048647521 cites W2041189737 @default.
- W3048647521 cites W2048620211 @default.
- W3048647521 cites W2049680858 @default.
- W3048647521 cites W2050302630 @default.
- W3048647521 cites W2053458902 @default.
- W3048647521 cites W2055725056 @default.
- W3048647521 cites W2055734417 @default.
- W3048647521 cites W2060529002 @default.
- W3048647521 cites W2061697468 @default.
- W3048647521 cites W2062201784 @default.
- W3048647521 cites W2062270243 @default.
- W3048647521 cites W2062767081 @default.
- W3048647521 cites W2063921163 @default.
- W3048647521 cites W2063927036 @default.
- W3048647521 cites W2065879385 @default.
- W3048647521 cites W2068435947 @default.
- W3048647521 cites W2070112477 @default.
- W3048647521 cites W2072027664 @default.
- W3048647521 cites W2084610968 @default.
- W3048647521 cites W2085904523 @default.
- W3048647521 cites W2087032263 @default.
- W3048647521 cites W2088081239 @default.
- W3048647521 cites W2092739280 @default.
- W3048647521 cites W2092822462 @default.
- W3048647521 cites W2094896519 @default.
- W3048647521 cites W2095998620 @default.
- W3048647521 cites W2097536972 @default.
- W3048647521 cites W2098032054 @default.