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- W3048649012 abstract "The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species transmission is not well understood. Here we simulated the SIVcpz initial transmission to humans using humanized mice and followed the viral evolution during serial passages lasting more than a year. All three SIVcpz progenitor viruses used, namely LB715 and MB897 (group M) as well as EK505 (group N) readily infected hu-mice resulting in chronic viremia. Viral loads increased progressively to higher set-points and the CD4+ T cell decline became more pronounced by the end of the second serial passage indicating viral adaptation and increased pathogenicity. Viral genomes sequenced at different time points revealed many nonsynonymous variants not previously reported that occurred throughout the viral genome, including the gag, pol, env and nef genes. These results shed light on the potential changes that the SIVcpz genome had undergone during the initial stages of human infection and subsequent spread." @default.
- W3048649012 created "2020-08-18" @default.
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- W3048649012 date "2020-08-11" @default.
- W3048649012 modified "2023-09-30" @default.
- W3048649012 title "Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice" @default.
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- W3048649012 cites W1933898011 @default.
- W3048649012 cites W1964807436 @default.
- W3048649012 cites W1964981073 @default.
- W3048649012 cites W1973208298 @default.
- W3048649012 cites W1976867329 @default.
- W3048649012 cites W1985623294 @default.
- W3048649012 cites W1990981237 @default.
- W3048649012 cites W1994122530 @default.
- W3048649012 cites W1995958102 @default.
- W3048649012 cites W2001375348 @default.
- W3048649012 cites W2003240710 @default.
- W3048649012 cites W2004330277 @default.
- W3048649012 cites W2010458160 @default.
- W3048649012 cites W2013769454 @default.
- W3048649012 cites W2015237638 @default.
- W3048649012 cites W2020743767 @default.
- W3048649012 cites W2022928393 @default.
- W3048649012 cites W2024814699 @default.
- W3048649012 cites W2025462995 @default.
- W3048649012 cites W2027853473 @default.
- W3048649012 cites W2030482575 @default.
- W3048649012 cites W2031598762 @default.
- W3048649012 cites W2033722707 @default.
- W3048649012 cites W2034858284 @default.
- W3048649012 cites W2036897871 @default.
- W3048649012 cites W2041515126 @default.
- W3048649012 cites W2044916494 @default.
- W3048649012 cites W2045628835 @default.
- W3048649012 cites W2054716809 @default.
- W3048649012 cites W2082314789 @default.
- W3048649012 cites W2083803997 @default.
- W3048649012 cites W2091660627 @default.
- W3048649012 cites W2099789019 @default.
- W3048649012 cites W2100119842 @default.
- W3048649012 cites W2103635075 @default.
- W3048649012 cites W2111776662 @default.
- W3048649012 cites W2115395564 @default.
- W3048649012 cites W2128461524 @default.
- W3048649012 cites W2130854667 @default.
- W3048649012 cites W2137950169 @default.
- W3048649012 cites W2140665904 @default.
- W3048649012 cites W2144373564 @default.
- W3048649012 cites W2146478787 @default.
- W3048649012 cites W2152683427 @default.
- W3048649012 cites W2153714632 @default.
- W3048649012 cites W2153747683 @default.
- W3048649012 cites W2156212256 @default.
- W3048649012 cites W2157615131 @default.
- W3048649012 cites W2157713905 @default.
- W3048649012 cites W2159181197 @default.
- W3048649012 cites W2165895151 @default.
- W3048649012 cites W2169199351 @default.
- W3048649012 cites W2170551349 @default.
- W3048649012 cites W2219893450 @default.
- W3048649012 cites W2434081591 @default.
- W3048649012 cites W2468450852 @default.
- W3048649012 cites W2557420930 @default.
- W3048649012 cites W2569231157 @default.
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- W3048649012 cites W2606667192 @default.
- W3048649012 cites W2616925143 @default.
- W3048649012 cites W2739269177 @default.
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- W3048649012 doi "https://doi.org/10.3389/fmicb.2020.01889" @default.
- W3048649012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7432304" @default.
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- W3048649012 hasPublicationYear "2020" @default.
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