FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048652267> ?p ?o ?g. }

• W3048652267 endingPage "654" @default.
• W3048652267 startingPage "635" @default.
• W3048652267 abstract "To improve the prognosis of upper tract urothelial carcinoma (UTUC), clinicians have used neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) before or after radical nephroureterectomy (RNU). Despite some new data, the evidence remains mixed on their efficacy.To update the current evidence on the role of NAC and AC for UTUC.We searched for all studies investigating NAC or AC for UTUC in Medline, Embase, the Cochrane Central Register of Controlled Trials, and abstracts from the American Society of Clinical Oncology meetings up to February 2020. A systematic review and meta-analysis was performed.For NAC, the pooled pathologic complete response rate (≤ypT0N0M0) was 11% (n = 811) and pathologic partial response rate (≤ypT1N0M0) was 43% (n = 869), both across 14 studies. Across six studies, the pooled hazard ratios (HRs) were 0.44 (95% confidence interval [CI]: 0.32-0.59, p < 0.001) for overall survival (OS) and 0.38 (95% CI: 0.24-0.61, p < 0.001) for cancer-specific survival (CSS) in favor of NAC. The evidence for NAC is at best level 2. As for AC, there was a benefit in OS (pooled HR 0.77; 95% CI: 0.64-0.92, p = 0.004 across 14 studies and 7983 patients), CSS (pooled HR 0.79; 95% CI: 0.69-0.91, p = 0.001 across 18 studies and 5659 patients), and disease-free survival (DFS; pooled HR 0.52; 95% CI: 0.38-0.70 across four studies and 602 patients). While most studies were retrospective (level 2 evidence), there were two prospective randomized trials providing level 1 evidence. There are currently four phase 2 trials on neoadjuvant immunotherapy and three phase 2 trials on adjuvant immunotherapy for UTUC.NAC for UTUC confers a favorable pathologic response and tumor downstaging rate, and an OS and CSS benefit compared with RNU alone. AC confers an OS, CSS, and DFS benefit compared with RNU alone. Currently, the evidence for AC appears stronger (with positive level 1 evidence) than that for NAC (at best level 2 evidence). Limited data are available for chemoimmunotherapy approaches, but preliminary data support an active research investment.After a comprehensive search of the latest studies examining the role of neoadjuvant and adjuvant chemotherapy for upper tract urothelial cancer, the pooled evidence shows that perioperative chemotherapy was beneficial for prolonging survival; however, the evidence for adjuvant chemotherapy was stronger than that for neoadjuvant chemotherapy." @default.
• W3048652267 created "2020-08-18" @default.
• W3048652267 creator A5012800133 @default.
• W3048652267 creator A5016482213 @default.
• W3048652267 creator A5025907365 @default.
• W3048652267 creator A5027828358 @default.
• W3048652267 creator A5048855238 @default.
• W3048652267 creator A5074756323 @default.
• W3048652267 date "2021-05-01" @default.
• W3048652267 modified "2023-10-14" @default.
• W3048652267 title "Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy" @default.
• W3048652267 cites W1494350978 @default.
• W3048652267 cites W1527366898 @default.
• W3048652267 cites W1594457607 @default.
• W3048652267 cites W1721273399 @default.
• W3048652267 cites W1771287927 @default.
• W3048652267 cites W1829677782 @default.
• W3048652267 cites W1967046314 @default.
• W3048652267 cites W1970462534 @default.
• W3048652267 cites W1971700963 @default.
• W3048652267 cites W1971956251 @default.
• W3048652267 cites W1974484906 @default.
• W3048652267 cites W1975677927 @default.
• W3048652267 cites W1979423827 @default.
• W3048652267 cites W1980525903 @default.
• W3048652267 cites W1987008857 @default.
• W3048652267 cites W1990070131 @default.
• W3048652267 cites W1992197403 @default.
• W3048652267 cites W2003123210 @default.
• W3048652267 cites W2008506518 @default.
• W3048652267 cites W2008984849 @default.
• W3048652267 cites W2014370222 @default.
• W3048652267 cites W2031998863 @default.
• W3048652267 cites W2032471331 @default.
• W3048652267 cites W2038111129 @default.
• W3048652267 cites W2046308359 @default.
• W3048652267 cites W2068972734 @default.
• W3048652267 cites W2080696159 @default.
• W3048652267 cites W2083083564 @default.
• W3048652267 cites W2083397917 @default.
• W3048652267 cites W2088095316 @default.
• W3048652267 cites W2099608113 @default.
• W3048652267 cites W2101691094 @default.
• W3048652267 cites W2116698483 @default.
• W3048652267 cites W2125435699 @default.
• W3048652267 cites W2138439591 @default.
• W3048652267 cites W2143756573 @default.
• W3048652267 cites W2149803495 @default.
• W3048652267 cites W2156098321 @default.
• W3048652267 cites W2157823046 @default.
• W3048652267 cites W2164876051 @default.
• W3048652267 cites W2166453367 @default.
• W3048652267 cites W2169443323 @default.
• W3048652267 cites W2171883057 @default.
• W3048652267 cites W2262926055 @default.
• W3048652267 cites W2409166821 @default.
• W3048652267 cites W2509447503 @default.
• W3048652267 cites W2563431589 @default.
• W3048652267 cites W2582834090 @default.
• W3048652267 cites W2589185576 @default.
• W3048652267 cites W2589765677 @default.
• W3048652267 cites W2604655222 @default.
• W3048652267 cites W2606085483 @default.
• W3048652267 cites W2610082023 @default.
• W3048652267 cites W2623134322 @default.
• W3048652267 cites W2737457347 @default.
• W3048652267 cites W2763573858 @default.
• W3048652267 cites W2767715878 @default.
• W3048652267 cites W2771296166 @default.
• W3048652267 cites W2772689211 @default.
• W3048652267 cites W2793179916 @default.
• W3048652267 cites W2888571497 @default.
• W3048652267 cites W2912579623 @default.
• W3048652267 cites W2920818871 @default.
• W3048652267 cites W2922806453 @default.
• W3048652267 cites W2941684372 @default.
• W3048652267 cites W2960130441 @default.
• W3048652267 cites W2964014383 @default.
• W3048652267 cites W2965065094 @default.
• W3048652267 cites W2969795737 @default.
• W3048652267 cites W2972385661 @default.
• W3048652267 cites W2978206750 @default.
• W3048652267 cites W2987068569 @default.
• W3048652267 cites W2987436342 @default.
• W3048652267 cites W2988581606 @default.
• W3048652267 cites W2991792334 @default.
• W3048652267 cites W2992893898 @default.
• W3048652267 cites W2994823935 @default.
• W3048652267 cites W2995612953 @default.
• W3048652267 cites W2997657090 @default.
• W3048652267 cites W2997881043 @default.
• W3048652267 cites W3007264925 @default.
• W3048652267 cites W3008833181 @default.
• W3048652267 cites W3012787501 @default.
• W3048652267 cites W3012836167 @default.
• W3048652267 cites W3032513350 @default.
• W3048652267 cites W4210259059 @default.
• W3048652267 cites W4230887698 @default.

• next