FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048652393> ?p ?o ?g. }

• W3048652393 abstract "<h3>Background:</h3> Rheumatoid arthritis (RA) is a chronic autoimmune disorder with not fully elucidate pathogenesis. Rheumatoid arthritis patients have increased risk of developing lymphomas. One of the possible mechanisms of this predisposition is increased genomic instability and impaired DNA repair. It is unclear how this genomic instability contributes to diseases pathogenesis. <h3>Objectives:</h3> The aim of this study was to analyze the sensitivity and repair efficiency of mononuclear cells isolated from RA patients to DNA damaging agents. <h3>Methods:</h3> The study group consisted of 22 patients with RA (age years - 60,77±13,00 women-17, men - 5) hospitalized in the Department of Rheumatology between 2017 and 2018 and 10 healthy controls without autoimmune and oncological diseases in clinical history (age 44,09±16,56; women-5, men-6). The peripheral blood mononuclear cells (PBMC) from all subjects were isolated. Using comet assay the degree of intracellular DNA damage as a result of exposure to standard damage factors: tert-butyl hydroperoxide (TBH), bleomycin, methyl methanesulfonate (MMS) and UV radiation was assessed. <h3>Results:</h3> RA patients show a statistically significant higher level of endogenous damage in PBMC DNA than controls (mean RA- 8,64% vs 4,68% in control; p<0,001). The extent of the DNA damage induced by TBH, MMS as well as UV was significantly higher in PBMC derived from RA patients than in healthy counterparts (p<0,001). The DNA of RA patients treated with TBH was repaired less effectively than in control (p<0,0001). Significantly higher percentage of DNA damage in RA DNA (p<0,0001) under the influence of bleomycin and clearly marked repair processes were observed. Among the healthy controls lower percentage of DNA was damaged, and although the repair process was slower but the final percent of DNA damage was lower than in RA cases (p<0,0001). <h3>Conclusion:</h3> DNA of people with rheumatoid arthritis is significantly more susceptible to damage in baseline and induced. The kinetics of DNA repair from RA patients after the introduction (TBH and bleomycin) was statistically less effective as compared to healthy control. Understanding the ethology of this phenomenon in RA may provide insight into disease pathogenesis and explain the increased susceptibility of patients to malignancies. <h3>Acknowledgement:</h3> The project is financed under the funds of the National Science Center (2017/25/B/NZ6/01358) <h3>Disclosure of Interests:</h3> None declared" @default.
• W3048652393 created "2020-08-18" @default.
• W3048652393 creator A5011214752 @default.
• W3048652393 creator A5038319132 @default.
• W3048652393 creator A5044956066 @default.
• W3048652393 creator A5052682626 @default.
• W3048652393 creator A5059575961 @default.
• W3048652393 creator A5069693901 @default.
• W3048652393 creator A5085265927 @default.
• W3048652393 date "2019-05-27" @default.
• W3048652393 modified "2023-10-18" @default.
• W3048652393 title "AB0002 INCREASED SENSITIVITY TO DNA DAMAGING AGENTS IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS" @default.
• W3048652393 cites W2008695042 @default.
• W3048652393 doi "https://doi.org/10.1136/annrheumdis-2019-eular.6155" @default.
• W3048652393 hasPublicationYear "2019" @default.
• W3048652393 type Work @default.
• W3048652393 sameAs 3048652393 @default.
• W3048652393 citedByCount "0" @default.
• W3048652393 crossrefType "proceedings-article" @default.
• W3048652393 hasAuthorship W3048652393A5011214752 @default.
• W3048652393 hasAuthorship W3048652393A5038319132 @default.
• W3048652393 hasAuthorship W3048652393A5044956066 @default.
• W3048652393 hasAuthorship W3048652393A5052682626 @default.
• W3048652393 hasAuthorship W3048652393A5059575961 @default.
• W3048652393 hasAuthorship W3048652393A5069693901 @default.
• W3048652393 hasAuthorship W3048652393A5085265927 @default.
• W3048652393 hasBestOaLocation W30486523931 @default.
• W3048652393 hasConcept C126322002 @default.
• W3048652393 hasConcept C137061746 @default.
• W3048652393 hasConcept C143425029 @default.
• W3048652393 hasConcept C178169997 @default.
• W3048652393 hasConcept C198451711 @default.
• W3048652393 hasConcept C202751555 @default.
• W3048652393 hasConcept C203014093 @default.
• W3048652393 hasConcept C2777575956 @default.
• W3048652393 hasConcept C2780358455 @default.
• W3048652393 hasConcept C2780942790 @default.
• W3048652393 hasConcept C54355233 @default.
• W3048652393 hasConcept C552990157 @default.
• W3048652393 hasConcept C55493867 @default.
• W3048652393 hasConcept C71924100 @default.
• W3048652393 hasConcept C86803240 @default.
• W3048652393 hasConceptScore W3048652393C126322002 @default.
• W3048652393 hasConceptScore W3048652393C137061746 @default.
• W3048652393 hasConceptScore W3048652393C143425029 @default.
• W3048652393 hasConceptScore W3048652393C178169997 @default.
• W3048652393 hasConceptScore W3048652393C198451711 @default.
• W3048652393 hasConceptScore W3048652393C202751555 @default.
• W3048652393 hasConceptScore W3048652393C203014093 @default.
• W3048652393 hasConceptScore W3048652393C2777575956 @default.
• W3048652393 hasConceptScore W3048652393C2780358455 @default.
• W3048652393 hasConceptScore W3048652393C2780942790 @default.
• W3048652393 hasConceptScore W3048652393C54355233 @default.
• W3048652393 hasConceptScore W3048652393C552990157 @default.
• W3048652393 hasConceptScore W3048652393C55493867 @default.
• W3048652393 hasConceptScore W3048652393C71924100 @default.
• W3048652393 hasConceptScore W3048652393C86803240 @default.
• W3048652393 hasLocation W30486523931 @default.
• W3048652393 hasOpenAccess W3048652393 @default.
• W3048652393 hasPrimaryLocation W30486523931 @default.
• W3048652393 hasRelatedWork W1614006528 @default.
• W3048652393 hasRelatedWork W2066486616 @default.
• W3048652393 hasRelatedWork W2114115007 @default.
• W3048652393 hasRelatedWork W2319650010 @default.
• W3048652393 hasRelatedWork W2373757429 @default.
• W3048652393 hasRelatedWork W2394298848 @default.
• W3048652393 hasRelatedWork W2410978906 @default.
• W3048652393 hasRelatedWork W3010479755 @default.
• W3048652393 hasRelatedWork W3121016581 @default.
• W3048652393 hasRelatedWork W2247530849 @default.
• W3048652393 isParatext "false" @default.
• W3048652393 isRetracted "false" @default.
• W3048652393 magId "3048652393" @default.
• W3048652393 workType "article" @default.