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- W3048652793 endingPage "2622" @default.
- W3048652793 startingPage "2622" @default.
- W3048652793 abstract "Bone metastasis develops in multiple malignancies with a wide range of incidence. The presence of multiple bone metastases, leading to a multitude of complications and poorer prognosis. The corresponding refractory bone pain is still a challenging issue managed through multidisciplinary approaches to enhance the quality of life. Radiopharmaceuticals are mainly used in the latest courses of the disease. Bone-pain palliation with easy-to-administer radionuclides offers advantages, including simultaneous treatment of multiple metastatic foci, the repeatability and also the combination with other therapies. Several β¯- and α-emitters as well as pharmaceuticals, from the very first [89Sr]strontium-dichloride to recently introduced [223Ra]radium-dichloride, are investigated to identify an optimum agent. In addition, the combination of bone-seeking radiopharmaceuticals with chemotherapy or radiotherapy has been employed to enhance the outcome. Radiopharmaceuticals demonstrate an acceptable response rate in pain relief. Nevertheless, survival benefits have been documented in only a limited number of studies. In this review, we provide an overview of bone-seeking radiopharmaceuticals used for bone-pain palliation, their effectiveness and toxicity, as well as the results of the combination with other therapies. Bone-pain palliation with radiopharmaceuticals has been employed for eight decades. However, there are still new aspects yet to be established." @default.
- W3048652793 created "2020-08-18" @default.
- W3048652793 creator A5028206922 @default.
- W3048652793 creator A5032276703 @default.
- W3048652793 creator A5038394289 @default.
- W3048652793 creator A5048598262 @default.
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- W3048652793 creator A5063841455 @default.
- W3048652793 creator A5066538954 @default.
- W3048652793 creator A5069183797 @default.
- W3048652793 date "2020-08-12" @default.
- W3048652793 modified "2023-09-25" @default.
- W3048652793 title "Targeted Palliative Radionuclide Therapy for Metastatic Bone Pain" @default.
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