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- W3048656531 endingPage "1613" @default.
- W3048656531 startingPage "1587" @default.
- W3048656531 abstract "Abstract Various treatments are found to be moderately effective in managing Demodex -related diseases except tea tree oil (TTO) and terpinen-4-ol (T4O), which showed superior miticidal and anti-inflammatory effects in numerous clinical studies. Their possible effects include lowering mite counts, relieving Demodex -related symptoms, and modulating the immune system. This review summarizes the current clinical topical and oral treatments in human demodicosis, their possible mechanisms of action, side-effects and resistance in treating this condition. TTO (especially T4O) is found to be the most effective followed by metronidazole, ivermectin and permethrin in managing the disease. This is because TTO has anti-parasitic, anti-bacterial, anti-fungal, anti-inflammatory and wound-healing effects. Furthermore, nanoTTO can even release its contents into fungus and Pseudomonas biofilms. Combinations of different treatments are occasionally needed for refractory cases, especially for individuals with underlying genetic predisposal or are immuno-compromised. Although the current treatments show efficacy in controlling the Demodex mite population and the related symptoms, further research needs to be focused on the efficacy and drug delivery technology in order to develop alternative treatments with better side-effects profiles, less toxicity, lower risk of resistance and are more cost-effective." @default.
- W3048656531 created "2020-08-18" @default.
- W3048656531 creator A5008768495 @default.
- W3048656531 creator A5011102609 @default.
- W3048656531 creator A5023431167 @default.
- W3048656531 creator A5029148652 @default.
- W3048656531 creator A5050654725 @default.
- W3048656531 creator A5078863586 @default.
- W3048656531 date "2020-08-10" @default.
- W3048656531 modified "2023-10-15" @default.
- W3048656531 title "Comparison of the efficacy of tea tree (<i>Melaleuca alternifolia</i>) oil with other current pharmacological management in human demodicosis: A Systematic Review" @default.
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