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• W3048656622 abstract "Abstract Background Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly understood, we and others have shown that altered gene expression and DNA methylation are implicated in disease pathogenesis. However, how DNA methylation might functionally impact gene expression and contribute to nerve damage remains unclear. Here, we analyzed genome-wide transcriptomic and methylomic profiles of sural nerves from T2D patients with DPN. Results Unbiased clustering of transcriptomics data separated samples into groups, which correlated with HbA1c levels. Accordingly, we found 998 differentially expressed genes (DEGs) and 929 differentially methylated genes (DMGs) between the groups with the highest and lowest HbA1c levels. Functional enrichment analysis revealed that DEGs and DMGs were enriched for pathways known to play a role in DPN, including those related to the immune system, extracellular matrix (ECM), and axon guidance. To understand the interaction between the transcriptome and methylome in DPN, we performed an integrated analysis of the overlapping genes between DEGs and DMGs. Integrated functional and network analysis identified genes and pathways modulating functions such as immune response, ECM regulation, and PI3K-Akt signaling. Conclusion These results suggest for the first time that DNA methylation is a mechanism regulating gene expression in DPN. Overall, DPN patients with high HbA1c have distinct alterations in sural nerve DNA methylome and transcriptome, suggesting that optimal glycemic control in DPN patients is an important factor in maintaining epigenetic homeostasis and nerve function." @default.
• W3048656622 created "2020-08-18" @default.
• W3048656622 creator A5012173640 @default.
• W3048656622 creator A5037824931 @default.
• W3048656622 creator A5038399373 @default.
• W3048656622 creator A5046996539 @default.
• W3048656622 creator A5068376728 @default.
• W3048656622 creator A5071436934 @default.
• W3048656622 date "2020-08-12" @default.
• W3048656622 modified "2023-10-18" @default.
• W3048656622 title "Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy" @default.
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• W3048656622 doi "https://doi.org/10.1186/s13148-020-00913-6" @default.
• W3048656622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7425575" @default.
• W3048656622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32787975" @default.
• W3048656622 hasPublicationYear "2020" @default.
• W3048656622 type Work @default.
• W3048656622 sameAs 3048656622 @default.

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