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- W3048658171 abstract "Constant or intense light degenerates the retina and retinal pigment epithelial cells. Light generates reactive oxygen species and nitric oxide leading to initial reactions of retinal degeneration. Apoptosis is the primary mechanism of abnormal death of photoreceptors, retinal ganglion cells, or retinal pigment epithelium (RPE) in degenerative retinal diseases, including diabetic retinopathy and age-related macular degeneration. The current study evaluated the function of erythropoietin (EPO) on angiogenesis and apoptosis in the retina and RPE under oxidative stress. We determined the pro-angiogenic and antiapoptotic mechanism of EPO under stress conditions using a conditional EPO knockdown model using siRNA, EPO addition, proteomics, immunocytochemistry, and bioinformatic analysis. Our studies verified that EPO protected retinal cells from light-, hypoxia-, hyperoxia-, and hydrogen peroxide-induced apoptosis through caspase inhibition, whereas up-regulated angiogenic reactions through vascular endothelial growth factor (VEGF) and angiotensin pathway. We demonstrated that the EPO expression in the retina and subsequent serine/threonine/tyrosine kinase phosphorylations might be linked to oxidative stress response tightly to determining angiogenesis and apoptosis. Neuroprotective roles of EPO may involve the balance between antiapoptotic and pro-angiogenic signaling molecules, including BCL-xL, c-FOS, caspase-3, nitric oxide, angiotensin, and VEGF receptor. Our data indicate a new therapeutic application of EPO toward retinal degeneration based on the dual roles in apoptosis and angiogenesis at the molecular level under oxidative stress." @default.
- W3048658171 created "2020-08-18" @default.
- W3048658171 creator A5024617951 @default.
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- W3048658171 date "2020-08-12" @default.
- W3048658171 modified "2023-09-25" @default.
- W3048658171 title "Dual Switch Mechanism of Erythropoietin as an Antiapoptotic and Pro-Angiogenic Determinant in the Retina" @default.
- W3048658171 cites W111387551 @default.
- W3048658171 cites W1424754343 @default.
- W3048658171 cites W1951772246 @default.
- W3048658171 cites W1965998396 @default.
- W3048658171 cites W1967334494 @default.
- W3048658171 cites W1968161608 @default.
- W3048658171 cites W1970588833 @default.
- W3048658171 cites W1971630204 @default.
- W3048658171 cites W1976805173 @default.
- W3048658171 cites W1978776187 @default.
- W3048658171 cites W1980466934 @default.
- W3048658171 cites W1982042273 @default.
- W3048658171 cites W1983911404 @default.
- W3048658171 cites W1988895001 @default.
- W3048658171 cites W1989440019 @default.
- W3048658171 cites W1990907264 @default.
- W3048658171 cites W1990932224 @default.
- W3048658171 cites W1991025036 @default.
- W3048658171 cites W1991317976 @default.
- W3048658171 cites W1996649203 @default.
- W3048658171 cites W1998006624 @default.
- W3048658171 cites W1998462333 @default.
- W3048658171 cites W2000464736 @default.
- W3048658171 cites W2002679216 @default.
- W3048658171 cites W2004659474 @default.
- W3048658171 cites W2008975983 @default.
- W3048658171 cites W2009331269 @default.
- W3048658171 cites W2011394755 @default.
- W3048658171 cites W2012838060 @default.
- W3048658171 cites W2014610874 @default.
- W3048658171 cites W2014978982 @default.
- W3048658171 cites W2018909644 @default.
- W3048658171 cites W2019864861 @default.
- W3048658171 cites W2020562174 @default.
- W3048658171 cites W2021258666 @default.
- W3048658171 cites W2024091883 @default.
- W3048658171 cites W2024486785 @default.
- W3048658171 cites W2025000308 @default.
- W3048658171 cites W2027803273 @default.
- W3048658171 cites W2027971364 @default.
- W3048658171 cites W2030718449 @default.
- W3048658171 cites W2031441113 @default.
- W3048658171 cites W2032103118 @default.
- W3048658171 cites W2035651311 @default.
- W3048658171 cites W2045694843 @default.
- W3048658171 cites W2046258960 @default.
- W3048658171 cites W2046580783 @default.
- W3048658171 cites W2051384280 @default.
- W3048658171 cites W2051943009 @default.
- W3048658171 cites W2051969780 @default.
- W3048658171 cites W2052839739 @default.
- W3048658171 cites W2055332529 @default.
- W3048658171 cites W2057128909 @default.
- W3048658171 cites W2058930880 @default.
- W3048658171 cites W2062253564 @default.
- W3048658171 cites W2071020911 @default.
- W3048658171 cites W2071719170 @default.
- W3048658171 cites W2077644908 @default.
- W3048658171 cites W2078511758 @default.
- W3048658171 cites W2079509305 @default.
- W3048658171 cites W2088471767 @default.
- W3048658171 cites W2109984060 @default.
- W3048658171 cites W2114112168 @default.
- W3048658171 cites W2118531218 @default.
- W3048658171 cites W2127168363 @default.
- W3048658171 cites W2130904237 @default.
- W3048658171 cites W2133134763 @default.
- W3048658171 cites W2135826900 @default.
- W3048658171 cites W2136137056 @default.
- W3048658171 cites W2139686570 @default.
- W3048658171 cites W2142463112 @default.
- W3048658171 cites W2147604739 @default.
- W3048658171 cites W2150008097 @default.
- W3048658171 cites W2150129386 @default.
- W3048658171 cites W2157296693 @default.
- W3048658171 cites W2158559578 @default.
- W3048658171 cites W2161605309 @default.
- W3048658171 cites W2164194503 @default.
- W3048658171 cites W2167779503 @default.
- W3048658171 cites W2169500091 @default.
- W3048658171 cites W2169958072 @default.
- W3048658171 cites W2170508225 @default.
- W3048658171 cites W2171524333 @default.