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- W3048658308 endingPage "2649" @default.
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- W3048658308 abstract "Phenylethanoid glycosides (PhGs) are generally water-soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest information on the biological activities, structure-activity relationships, mechanisms, and especially the clinical applications of PhGs will be reviewed. The bioavailability of PhGs will be summarized and factors leading to the low bioavailability will be analyzed. Recent advances in methods such as bioenhancers and nanotechnology to improve the bioavailability of PhGs are also summarized. The existing scientific gaps of PhGs in knowledge are also discussed, highlighting research directions in the future." @default.
- W3048658308 created "2020-08-18" @default.
- W3048658308 creator A5012769245 @default.
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- W3048658308 creator A5030777903 @default.
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- W3048658308 creator A5059448943 @default.
- W3048658308 date "2020-08-10" @default.
- W3048658308 modified "2023-10-14" @default.
- W3048658308 title "Therapeutic potential of phenylethanoid glycosides: A systematic review" @default.
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