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• W3048658321 startingPage "1899" @default.
• W3048658321 abstract "Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the pathophysiological development and organization of cells in the vegetation, most notably the primordial role of platelets and further triggered hemostasis, which is related to the diversity of infectious microorganisms involved. Our objective was to study the organization of IE vegetations due to different bacteria species in order to understand the related pathophysiological mechanism of vegetation development. We present an approach for ultrastructural analysis of whole-infected heart valve tissue based on scanning electron microscopy and energy-dispersive X-ray spectroscopy. Our approach allowed us to detect differences in cell organization between the analyzed vegetations and revealed a distinct chemical feature in viridans Streptococci ones. Our results illustrate the benefits that such an approach may bring for guiding therapy, considering the germ involved for each IE patient." @default.
• W3048658321 created "2020-08-18" @default.
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• W3048658321 date "2020-08-13" @default.
• W3048658321 modified "2023-09-26" @default.
• W3048658321 title "A Novel Approach for Detecting Unique Variations among Infectious Bacterial Species in Endocarditic Cardiac Valve Vegetation" @default.
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• W3048658321 doi "https://doi.org/10.3390/cells9081899" @default.
• W3048658321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7464176" @default.
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