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• W3048658364 endingPage "2006" @default.
• W3048658364 startingPage "1991" @default.
• W3048658364 abstract "The spliceostatins/thailanstatins are a family of linear peptides/polyketides that inhibit pre-mRNA splicing, and as such act as potent cytotoxic compounds. These compounds generally contain 9 stereocenters spread over a common (2 Z ,4 S )-4-acetoxy-2-butenamide fragment, an (all- cis )-2,3,5,6-tetrasubstituted tetrahydropyran fragment and a terminal oxane ring joined by a dienyl chain. Due to the impressive antitumor properties of these compounds, along with their complex structure, a number of total syntheses have been reported. This review will compare the synthetic strategies reported through the end of 2019." @default.
• W3048658364 created "2020-08-18" @default.
• W3048658364 creator A5087049665 @default.
• W3048658364 date "2020-08-13" @default.
• W3048658364 modified "2023-09-30" @default.
• W3048658364 title "Syntheses of spliceostatins and thailanstatins: a review" @default.
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• W3048658364 doi "https://doi.org/10.3762/bjoc.16.166" @default.
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