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• W3048658944 abstract "The highly destructive mechanisms by which the immune system faces microbial infections is under the control of a series of inhibitory receptors. While most of these receptors prevent unwanted/excessive responses of individual effector cells, others play a more general role in immunity, acting as true inhibitory checkpoints controlling both innate and adaptive immunity. Regarding human NK cells, their function is finely regulated by HLA-class I-specific inhibitory receptors which allow discrimination between HLA-I+, healthy cells and tumor or virus-infected cells displaying loss or substantial alterations of HLA-I molecules, including allelic losses that are sensed by KIRs. A number of non-HLA-specific receptors have been identified which recognize cell surface or extracellular matrix ligands and may contribute to the physiologic control of immune responses and tolerance. Among these receptors, Siglec 7 (p75/AIRM-1), LAIR-1 and IRp60, recognize ligands including sialic acids, extracellular matrix/collagen or aminophospholipids, respectively. These ligands may be expressed at the surface of tumor cells, thus inhibiting NK cell function. Expression of the PD-1 checkpoint by NK cells requires particular cytokines (IL-15, IL-12, IL-18) together with cortisol, a combination which may occur in the microenvironment of different tumors. Blocking of single or combinations of inhibitory receptors unleashes NK cells and restore their anti-tumor activity, with obvious implications for tumor immunotherapy." @default.
• W3048658944 created "2020-08-18" @default.
• W3048658944 creator A5006521329 @default.
• W3048658944 creator A5020843731 @default.
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• W3048658944 creator A5027162539 @default.
• W3048658944 creator A5029764194 @default.
• W3048658944 creator A5034149467 @default.
• W3048658944 creator A5035849763 @default.
• W3048658944 creator A5050703359 @default.
• W3048658944 creator A5052988199 @default.
• W3048658944 creator A5086571593 @default.
• W3048658944 creator A5091853374 @default.
• W3048658944 date "2020-09-03" @default.
• W3048658944 modified "2023-10-18" @default.
• W3048658944 title "Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer" @default.
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