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• W3048659577 abstract "Abstract Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 is shown to reduce amyloid-β (Aβ) clearance and exacerbate Aβ peptide accumulation in plaques and vessels of Alzheimer’s disease mouse models, the mechanism and clearing pathways involved are debated. Here, we investigated how inhibiting the function of AQP4 in healthy male C57BL/6 J mice impacts clearance of Aβ40, the more soluble Aβ isoform. Using two-photon in vivo imaging and visualizing vessels with Sulfurodamine 101 (SR101), we first showed that Aβ40 injected as a ≤ 0.5-μl volume in the cerebral cortex diffused rapidly in parenchyma and accumulated around blood vessels. In animals treated with the AQP4 inhibitor TGN-020, the perivascular Aβ40 accumulation was significantly ( P < 0.001) intensified by involving four times more vessels, thus suggesting a generalized clearance defect associated with vessels. Increasing the injecting volume to ≥ 0.5 ≤ 1 μl decreased the difference of Aβ40-positive vessels observed in non-treated and AQP4 inhibitor-treated animals, although the difference was still significant ( P = 0.001), suggesting that larger injection volumes could overwhelm intramural vascular clearance mechanisms. While both small and large vessels accumulated Aβ40, for the ≤ 0.5-μl volume group, the average diameter of the Aβ40-positive vessels tended to be larger in control animals compared with TGN-020-treated animals, although the difference was non-significant ( P = 0.066). Using histopathology and ultrastructural microscopy, no vascular structural change was observed after a single massive dose of TGN-020. These data suggest that AQP4 deficiency is directly involved in impaired Aβ brain clearance via the peri-/para-vascular routes, and AQP4-mediated vascular clearance might counteract blood-brain barrier abnormalities and age-related vascular amyloidopathy." @default.
• W3048659577 created "2020-08-18" @default.
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• W3048659577 date "2020-08-11" @default.
• W3048659577 modified "2023-10-18" @default.
• W3048659577 title "Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels" @default.
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• W3048659577 cites W1561114541 @default.
• W3048659577 cites W1580500775 @default.
• W3048659577 cites W1591974057 @default.
• W3048659577 cites W1592806007 @default.
• W3048659577 cites W1603244154 @default.
• W3048659577 cites W1761818158 @default.
• W3048659577 cites W1894872962 @default.
• W3048659577 cites W1923535990 @default.
• W3048659577 cites W1967036214 @default.
• W3048659577 cites W1977011271 @default.
• W3048659577 cites W1980786936 @default.
• W3048659577 cites W1985063020 @default.
• W3048659577 cites W1989206786 @default.
• W3048659577 cites W1993064394 @default.
• W3048659577 cites W1994698746 @default.
• W3048659577 cites W1997822484 @default.
• W3048659577 cites W1998208719 @default.
• W3048659577 cites W2006035554 @default.
• W3048659577 cites W2011991034 @default.
• W3048659577 cites W2020526702 @default.
• W3048659577 cites W2028623620 @default.
• W3048659577 cites W2028663372 @default.
• W3048659577 cites W2031880534 @default.
• W3048659577 cites W2035219683 @default.
• W3048659577 cites W2040048997 @default.
• W3048659577 cites W2041851050 @default.
• W3048659577 cites W2051764450 @default.
• W3048659577 cites W2054325717 @default.
• W3048659577 cites W2060701169 @default.
• W3048659577 cites W2064057102 @default.
• W3048659577 cites W2067766876 @default.
• W3048659577 cites W2069546586 @default.
• W3048659577 cites W2070251027 @default.
• W3048659577 cites W2072631903 @default.
• W3048659577 cites W2075431576 @default.
• W3048659577 cites W2075930760 @default.
• W3048659577 cites W2076015301 @default.
• W3048659577 cites W2078736055 @default.
• W3048659577 cites W2079477479 @default.
• W3048659577 cites W2088151512 @default.
• W3048659577 cites W2091722185 @default.
• W3048659577 cites W2091880370 @default.
• W3048659577 cites W2095563693 @default.
• W3048659577 cites W2096410114 @default.
• W3048659577 cites W2096963202 @default.
• W3048659577 cites W2108149991 @default.
• W3048659577 cites W2119734225 @default.
• W3048659577 cites W2125368074 @default.
• W3048659577 cites W2139667731 @default.
• W3048659577 cites W2142514276 @default.
• W3048659577 cites W2151849193 @default.
• W3048659577 cites W2152719134 @default.
• W3048659577 cites W2156751516 @default.
• W3048659577 cites W2167183660 @default.
• W3048659577 cites W2172922484 @default.
• W3048659577 cites W2298591538 @default.
• W3048659577 cites W2298946842 @default.
• W3048659577 cites W2346742153 @default.
• W3048659577 cites W2570323671 @default.
• W3048659577 cites W2601770895 @default.
• W3048659577 cites W2734645299 @default.
• W3048659577 cites W2779234199 @default.
• W3048659577 cites W2789907674 @default.
• W3048659577 cites W2801110912 @default.
• W3048659577 cites W2916037674 @default.
• W3048659577 cites W2944666647 @default.
• W3048659577 cites W2945986004 @default.
• W3048659577 cites W2986056418 @default.
• W3048659577 cites W4233842380 @default.
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• W3048659577 doi "https://doi.org/10.1007/s12035-020-02044-8" @default.
• W3048659577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7515968" @default.
• W3048659577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32783141" @default.
• W3048659577 hasPublicationYear "2020" @default.
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