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• W3048660427 abstract "Abstract Misuse of prescription medications has risen to popularity. Reasons for this practice include the self-medication of sleep and psychiatric disorders and attempts to counteract the dysphoric side effects of stimulant drugs. Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety. As both substances may impair sleep and aggravate psychiatric conditions, this study aimed to evaluate the long-term effects of the interaction of clonazepam and cocaine on anxiety-like behavior, and the short-term effects of this drug combination on sleep using male Wistar rats. Animals received saline, cocaine (15 mg/kg), clonazepam (1.25 mg/kg) or both drugs for 16 days. Sleep recording was performed on the first day of treatment to evaluate acute treatment effects. One day after the end of the treatment period, the open field and elevated plus-maze tests were used to assess anxiety-like behavior. Blood samples were collected for analysis of corticosterone levels. Rats receiving both drugs presented an increase in impulsivity when moving between arms in the elevated plus-maze and a reduction in exploratory behavior in the open field test. These findings suggest the presence of a withdrawal behavioral syndrome, which can manifest as a paradoxical increase in exploratory activity after a period without receiving the drug and may indicate the development of dependence. Combined treatment reduced paradoxical sleep time and increased its onset latency. There was no significant difference regarding corticosterone levels across any group. Our results contribute to the understanding of the risks of combining cocaine and clonazepam. Association of these drugs may impair sleep architecture and aggravate the dependence symptoms already seen when these substances are used separately. These findings may be useful in helping to counteract the impairments resulting from the combined use of these 2 substances and to raise awareness of these associated risks." @default.
• W3048660427 created "2020-08-18" @default.
• W3048660427 creator A5006345872 @default.
• W3048660427 creator A5008570805 @default.
• W3048660427 creator A5008797723 @default.
• W3048660427 creator A5077926189 @default.
• W3048660427 date "2020-10-01" @default.
• W3048660427 modified "2023-10-03" @default.
• W3048660427 title "Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats" @default.
• W3048660427 cites W1581662254 @default.
• W3048660427 cites W1664641772 @default.
• W3048660427 cites W1759349092 @default.
• W3048660427 cites W1964160578 @default.
• W3048660427 cites W1966037459 @default.
• W3048660427 cites W1968104310 @default.
• W3048660427 cites W1968899932 @default.
• W3048660427 cites W1971928349 @default.
• W3048660427 cites W1975817655 @default.
• W3048660427 cites W1979554448 @default.
• W3048660427 cites W1983691295 @default.
• W3048660427 cites W1984414190 @default.
• W3048660427 cites W1984703718 @default.
• W3048660427 cites W1987492017 @default.
• W3048660427 cites W1989207025 @default.
• W3048660427 cites W1991354131 @default.
• W3048660427 cites W1999407922 @default.
• W3048660427 cites W1999762915 @default.
• W3048660427 cites W2000576334 @default.
• W3048660427 cites W200104589 @default.
• W3048660427 cites W2001308670 @default.
• W3048660427 cites W2010100547 @default.
• W3048660427 cites W2016665188 @default.
• W3048660427 cites W2018835797 @default.
• W3048660427 cites W2024401754 @default.
• W3048660427 cites W2024901368 @default.
• W3048660427 cites W2025999902 @default.
• W3048660427 cites W2028029441 @default.
• W3048660427 cites W2029052259 @default.
• W3048660427 cites W2030736328 @default.
• W3048660427 cites W2032405254 @default.
• W3048660427 cites W2033875883 @default.
• W3048660427 cites W2036051176 @default.
• W3048660427 cites W2038521791 @default.
• W3048660427 cites W2041411486 @default.
• W3048660427 cites W2044553756 @default.
• W3048660427 cites W2045469853 @default.
• W3048660427 cites W2046072079 @default.
• W3048660427 cites W2051814352 @default.
• W3048660427 cites W2062697655 @default.
• W3048660427 cites W2065417208 @default.
• W3048660427 cites W2067292729 @default.
• W3048660427 cites W2067825638 @default.
• W3048660427 cites W2072938112 @default.
• W3048660427 cites W2074807110 @default.
• W3048660427 cites W2083456249 @default.
• W3048660427 cites W2084071932 @default.
• W3048660427 cites W2093984019 @default.
• W3048660427 cites W2095133395 @default.
• W3048660427 cites W2102429943 @default.
• W3048660427 cites W2104952417 @default.
• W3048660427 cites W2111267491 @default.
• W3048660427 cites W2120159804 @default.
• W3048660427 cites W2122062108 @default.
• W3048660427 cites W2148775404 @default.
• W3048660427 cites W2160997565 @default.
• W3048660427 cites W2164822993 @default.
• W3048660427 cites W2166436976 @default.
• W3048660427 cites W2174045819 @default.
• W3048660427 cites W2184913327 @default.
• W3048660427 cites W2200849634 @default.
• W3048660427 cites W2281058637 @default.
• W3048660427 cites W2288867009 @default.
• W3048660427 cites W2306402428 @default.
• W3048660427 cites W2332602680 @default.
• W3048660427 cites W2341457713 @default.
• W3048660427 cites W2345034759 @default.
• W3048660427 cites W2413376255 @default.
• W3048660427 cites W2417894527 @default.
• W3048660427 cites W2484268986 @default.
• W3048660427 cites W2506612224 @default.
• W3048660427 cites W2543609654 @default.
• W3048660427 cites W2560072852 @default.
• W3048660427 cites W2619131632 @default.
• W3048660427 cites W2755653193 @default.
• W3048660427 cites W2770217313 @default.
• W3048660427 cites W2773584640 @default.
• W3048660427 cites W43585160 @default.
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• W3048660427 doi "https://doi.org/10.1016/j.pbb.2020.173014" @default.
• W3048660427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795565" @default.
• W3048660427 hasPublicationYear "2020" @default.
• W3048660427 type Work @default.
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• W3048660427 hasAuthorship W3048660427A5006345872 @default.
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• W3048660427 hasAuthorship W3048660427A5008797723 @default.

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