FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048668798> ?p ?o ?g. }

• W3048668798 endingPage "e0235501" @default.
• W3048668798 startingPage "e0235501" @default.
• W3048668798 abstract "Cardiovascular disease (CVD) and venous thromboembolism (VTE) figure among the main causes of morbidity and mortality in modern societies. Although associated with distinct pathogenic mechanisms, epidemiological, experimental and clinical trial data suggest that the mechanisms responsible for arterial and venous thrombosis are at least partially overlapped. Herein we aimed to explore shared and discordant pathways involved in the pathogenesis of VTE and CVD at the transcriptomic level and to validate the results in independent cohorts. Five public datasets of gene expression data from VTE and CVD (myocardial infarction, peripheral arterial occlusive disease and stroke) patients were analyzed using an integrative bioinformatic strategy. A machine/statistical learning method was used to derive classifiers for the discrimination of VTE and CVD, and tested in independent datasets. Two sets of genes that were commonly (n = 472) or divergently (n = 124) expressed in CVD and VTE were identified. Genes and pathways associated with innate immune function were over-represented in both conditions, along with pathways associated with complement and hemostasis. Pathways associated with neutrophil activation and with IL-1 signaling were also enriched in CVD compared to VTE. The gene expression signature of VTE more closely resembled the pattern of cardioembolic stroke than the patterns of acute myocardial infarction, ischemic stroke and peripheral arterial occlusive disease. Classifiers derived from these gene lists accurately discriminated patients with VTE and CVD from independent cohorts. In conclusion, our results add a new set of data at the transcriptomic level for future studies between arterial and venous thrombosis. Strengths and limitations of this study Our results represent the first comparison of venous and arterial thrombosis at the transcriptomic level. Our main result was the demonstration that immunothrombosis pathways are important to the pathophysiology of these conditions, also at the transcriptomic level. A specific signature for venous and arterial thrombosis was described, and validated in independent cohorts. The limited number of public repositories with gene expression data from patients with venous thromboembolism limits the representation of these patients in our analyses. In order to gather a meaningful number of studies with gene expression data we had to include patients in different time-points since the index thrombotic event, which might have increased the heterogeneity of our population." @default.
• W3048668798 created "2020-08-18" @default.
• W3048668798 creator A5014248896 @default.
• W3048668798 creator A5073059240 @default.
• W3048668798 creator A5073322625 @default.
• W3048668798 creator A5090489122 @default.
• W3048668798 date "2020-08-11" @default.
• W3048668798 modified "2023-10-14" @default.
• W3048668798 title "Identification of common and divergent gene expression signatures in patients with venous and arterial thrombosis using data from public repositories" @default.
• W3048668798 cites W1465330238 @default.
• W3048668798 cites W1760726760 @default.
• W3048668798 cites W1818409119 @default.
• W3048668798 cites W1913879859 @default.
• W3048668798 cites W1975990989 @default.
• W3048668798 cites W1976442910 @default.
• W3048668798 cites W1979392717 @default.
• W3048668798 cites W1981849943 @default.
• W3048668798 cites W1981933966 @default.
• W3048668798 cites W1983855408 @default.
• W3048668798 cites W1991796833 @default.
• W3048668798 cites W2006666326 @default.
• W3048668798 cites W2013710547 @default.
• W3048668798 cites W2020541351 @default.
• W3048668798 cites W2030063068 @default.
• W3048668798 cites W2033896075 @default.
• W3048668798 cites W2042991344 @default.
• W3048668798 cites W2045220907 @default.
• W3048668798 cites W2045949302 @default.
• W3048668798 cites W2047190758 @default.
• W3048668798 cites W2047718818 @default.
• W3048668798 cites W2050000912 @default.
• W3048668798 cites W2051761295 @default.
• W3048668798 cites W2051990009 @default.
• W3048668798 cites W2064369146 @default.
• W3048668798 cites W2068886931 @default.
• W3048668798 cites W2070050178 @default.
• W3048668798 cites W2079604465 @default.
• W3048668798 cites W2082475943 @default.
• W3048668798 cites W2087967308 @default.
• W3048668798 cites W2092241757 @default.
• W3048668798 cites W2102489984 @default.
• W3048668798 cites W2107321252 @default.
• W3048668798 cites W2107327653 @default.
• W3048668798 cites W2109307547 @default.
• W3048668798 cites W2115989954 @default.
• W3048668798 cites W2118659478 @default.
• W3048668798 cites W2120865735 @default.
• W3048668798 cites W2125312486 @default.
• W3048668798 cites W2130410032 @default.
• W3048668798 cites W2130449777 @default.
• W3048668798 cites W2135849676 @default.
• W3048668798 cites W2136057525 @default.
• W3048668798 cites W2144856532 @default.
• W3048668798 cites W2146111996 @default.
• W3048668798 cites W2148708580 @default.
• W3048668798 cites W2149298154 @default.
• W3048668798 cites W2154981570 @default.
• W3048668798 cites W2158519357 @default.
• W3048668798 cites W2160264312 @default.
• W3048668798 cites W2161167193 @default.
• W3048668798 cites W2161735825 @default.
• W3048668798 cites W2162531249 @default.
• W3048668798 cites W2167365973 @default.
• W3048668798 cites W2192733338 @default.
• W3048668798 cites W2215583678 @default.
• W3048668798 cites W2255567127 @default.
• W3048668798 cites W2338861620 @default.
• W3048668798 cites W2344977044 @default.
• W3048668798 cites W2349457619 @default.
• W3048668798 cites W2406250479 @default.
• W3048668798 cites W2419349850 @default.
• W3048668798 cites W2466838272 @default.
• W3048668798 cites W2608461297 @default.
• W3048668798 cites W2611826771 @default.
• W3048668798 cites W2728238329 @default.
• W3048668798 cites W2733047156 @default.
• W3048668798 cites W2748400555 @default.
• W3048668798 cites W2749380187 @default.
• W3048668798 cites W2751949016 @default.
• W3048668798 cites W2757112680 @default.
• W3048668798 cites W2783189216 @default.
• W3048668798 cites W2785490330 @default.
• W3048668798 cites W2786085951 @default.
• W3048668798 cites W2786262376 @default.
• W3048668798 cites W2789502013 @default.
• W3048668798 cites W2803799996 @default.
• W3048668798 cites W2805310212 @default.
• W3048668798 cites W2805508285 @default.
• W3048668798 cites W2805697348 @default.
• W3048668798 cites W2805921025 @default.
• W3048668798 cites W2808054672 @default.
• W3048668798 cites W2888953082 @default.
• W3048668798 cites W2890257935 @default.
• W3048668798 cites W2898156042 @default.
• W3048668798 cites W2910451516 @default.
• W3048668798 cites W2916627882 @default.
• W3048668798 cites W2919079215 @default.
• W3048668798 cites W2923086212 @default.

• next