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- W3048672197 endingPage "1214" @default.
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- W3048672197 abstract "Abstract The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner mitochondrial membrane which is essential for oxidative phosphorylation under physiological conditions. In this review, we analyse the enzyme functions involved in cancer progression by dissecting specific conditions in which ATP synthase contributes to cancer development or metastasis. Moreover, we propose the role of ATP synthase in the formation of the permeability transition pore (PTP) as an additional mechanism which controls tumour cell death. We further describe transcriptional and translational modifications of the enzyme subunits and of the inhibitor protein IF1 that may promote adaptations leading to cancer metabolism. Finally, we outline ATP synthase gene mutations and epigenetic modifications associated with cancer development or drug resistance, with the aim of highlighting this enzyme complex as a potential novel target for future anti-cancer therapy." @default.
- W3048672197 created "2020-08-18" @default.
- W3048672197 creator A5003543778 @default.
- W3048672197 creator A5006392634 @default.
- W3048672197 creator A5046118465 @default.
- W3048672197 creator A5064932458 @default.
- W3048672197 date "2020-08-24" @default.
- W3048672197 modified "2023-10-14" @default.
- W3048672197 title "The role of mitochondrial ATP synthase in cancer" @default.
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