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- W3048674217 endingPage "108024" @default.
- W3048674217 startingPage "108024" @default.
- W3048674217 abstract "The ability to remodel lipid metabolism under changing conditions is pivotal for cellular functionality and homeostasis. Here, we characterize the regulatory landscape of phosphorylation-based signaling events across the life cycle of Saccharomyces cerevisiae and determine its impact on the regulation of lipid metabolism. Our data show that 50 lipid metabolic proteins are differentially phosphorylated as cells transit between different physiological states. To identify functional phosphosites, we devised a strategy where multiple phosphosites are simultaneously mutated into phosphomimetic or phosphodeficient alleles and mutants are phenotyped by in-depth lipidomics flux analysis. This uncovers functional phosphosites in the phosphatidate cytidylyltransferase Cds1, the phosphatidylserine synthase Cho1, and Fas2, the α-subunit of the fatty acid synthase (FAS) complex. Furthermore, we show that the fatty acyl chain length produced by FAS is governed by phosphorylation. Overall, our work demonstrates a vital role for phosphoregulation of lipid metabolism and provides a resource to investigate its molecular underpinnings." @default.
- W3048674217 created "2020-08-18" @default.
- W3048674217 creator A5009310130 @default.
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- W3048674217 creator A5059578665 @default.
- W3048674217 creator A5084454705 @default.
- W3048674217 date "2020-08-01" @default.
- W3048674217 modified "2023-10-15" @default.
- W3048674217 title "Phosphoproteomic Analysis across the Yeast Life Cycle Reveals Control of Fatty Acyl Chain Length by Phosphorylation of the Fatty Acid Synthase Complex" @default.
- W3048674217 cites W1504478980 @default.
- W3048674217 cites W1598193192 @default.
- W3048674217 cites W1617495083 @default.
- W3048674217 cites W1803838592 @default.
- W3048674217 cites W1971637500 @default.
- W3048674217 cites W1974983216 @default.
- W3048674217 cites W1974984123 @default.
- W3048674217 cites W1980992560 @default.
- W3048674217 cites W1984450835 @default.
- W3048674217 cites W1984954439 @default.
- W3048674217 cites W1986887325 @default.
- W3048674217 cites W1992140809 @default.
- W3048674217 cites W1993423688 @default.
- W3048674217 cites W2016722924 @default.
- W3048674217 cites W2020972228 @default.
- W3048674217 cites W2026926544 @default.
- W3048674217 cites W2028974980 @default.
- W3048674217 cites W2032315776 @default.
- W3048674217 cites W2032977708 @default.
- W3048674217 cites W2043204396 @default.
- W3048674217 cites W2045439860 @default.
- W3048674217 cites W2047373064 @default.
- W3048674217 cites W2053433344 @default.
- W3048674217 cites W2053943711 @default.
- W3048674217 cites W2055163987 @default.
- W3048674217 cites W2058297557 @default.
- W3048674217 cites W2058333934 @default.
- W3048674217 cites W2059085198 @default.
- W3048674217 cites W2066892896 @default.
- W3048674217 cites W2068749469 @default.
- W3048674217 cites W2070380343 @default.
- W3048674217 cites W2074352392 @default.
- W3048674217 cites W2079559417 @default.
- W3048674217 cites W2081098333 @default.
- W3048674217 cites W2083462910 @default.
- W3048674217 cites W2094178975 @default.
- W3048674217 cites W2094190866 @default.
- W3048674217 cites W2097337993 @default.
- W3048674217 cites W2097423540 @default.
- W3048674217 cites W2103370167 @default.
- W3048674217 cites W2112520822 @default.
- W3048674217 cites W2114881940 @default.
- W3048674217 cites W2115168068 @default.
- W3048674217 cites W2117484859 @default.
- W3048674217 cites W2120328280 @default.
- W3048674217 cites W2121893632 @default.
- W3048674217 cites W2128134586 @default.
- W3048674217 cites W2131987549 @default.
- W3048674217 cites W2134957504 @default.
- W3048674217 cites W2142250746 @default.
- W3048674217 cites W2146411852 @default.
- W3048674217 cites W2147098506 @default.
- W3048674217 cites W2148053098 @default.
- W3048674217 cites W2160238206 @default.
- W3048674217 cites W2165630230 @default.
- W3048674217 cites W2168797545 @default.
- W3048674217 cites W2168974130 @default.
- W3048674217 cites W2174118934 @default.
- W3048674217 cites W2238883961 @default.
- W3048674217 cites W2325375737 @default.
- W3048674217 cites W2342067135 @default.
- W3048674217 cites W2436363168 @default.
- W3048674217 cites W2515712756 @default.
- W3048674217 cites W2530330401 @default.
- W3048674217 cites W2576890255 @default.
- W3048674217 cites W2594152625 @default.
- W3048674217 cites W2769632036 @default.
- W3048674217 cites W2769988418 @default.
- W3048674217 cites W2783186574 @default.
- W3048674217 cites W2790705492 @default.
- W3048674217 cites W2794383917 @default.
- W3048674217 cites W2798235127 @default.
- W3048674217 cites W2804360210 @default.
- W3048674217 cites W2804741598 @default.
- W3048674217 cites W2904499052 @default.
- W3048674217 cites W2906084186 @default.
- W3048674217 cites W2938629106 @default.
- W3048674217 cites W2950941748 @default.
- W3048674217 cites W2953375613 @default.
- W3048674217 cites W2973787136 @default.
- W3048674217 cites W2975095890 @default.
- W3048674217 cites W2982048632 @default.