FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048683609> ?p ?o ?g. }

• W3048683609 endingPage "1938" @default.
• W3048683609 startingPage "1926" @default.
• W3048683609 abstract "Aberrant expression of transforming growth factor-β1 (TGF-β1) is associated with renal cell carcinoma (RCC) progression by inducing cancer metastasis. However, the downstream effector(s) in TGF-β signaling pathway is not fully characterized. In the present study, the elevation of secreted protein acidic and rich in cysteine (SPARC) as a TGF-β regulated gene in RCC was identified by applying differentially expressed gene analysis and microarray analysis, we further confirmed this result in several RCC cell lines. Clinically, the expression of these two genes is positively correlated in RCC patient specimens. Furthermore, elevated SPARC expression is found in all the subtypes of RCC and positively correlated with the RCC stage and grade. In contrast, SPARC expression is inversely correlated with overall and disease-free survival of patients with RCC, suggesting SPARC as a potent prognostic marker of RCC patient survival. Knocking down SPARC significantly inhibits RCC cell invasion and metastasis both in vitro and in vivo. Similarly, in vitro cell invasion can be diminished by using a specific monoclonal antibody. Mechanistically, SPARC activates protein kinase B (AKT) pathway leading to elevated expression of matrix metalloproteinase-2 that can facilitate RCC invasion. Altogether, our data support that SPARC is a critical role of TGF-β signaling network underlying RCC progression and a potential therapeutic target as well as a prognostic marker." @default.
• W3048683609 created "2020-08-18" @default.
• W3048683609 creator A5005228021 @default.
• W3048683609 creator A5007989892 @default.
• W3048683609 creator A5015579895 @default.
• W3048683609 creator A5027980950 @default.
• W3048683609 creator A5029404358 @default.
• W3048683609 creator A5040462812 @default.
• W3048683609 creator A5066931842 @default.
• W3048683609 creator A5069595062 @default.
• W3048683609 creator A5073466957 @default.
• W3048683609 creator A5076107662 @default.
• W3048683609 creator A5079568312 @default.
• W3048683609 creator A5082156719 @default.
• W3048683609 creator A5083093401 @default.
• W3048683609 creator A5085071616 @default.
• W3048683609 creator A5088408355 @default.
• W3048683609 creator A5089104361 @default.
• W3048683609 creator A5090605165 @default.
• W3048683609 creator A5091753897 @default.
• W3048683609 date "2020-08-11" @default.
• W3048683609 modified "2023-10-18" @default.
• W3048683609 title "SPARC is a key mediator of TGF‐β‐induced renal cancer metastasis" @default.
• W3048683609 cites W1132654112 @default.
• W3048683609 cites W1757407923 @default.
• W3048683609 cites W1969706233 @default.
• W3048683609 cites W1982066003 @default.
• W3048683609 cites W1986471913 @default.
• W3048683609 cites W1991816023 @default.
• W3048683609 cites W1998790582 @default.
• W3048683609 cites W2004099033 @default.
• W3048683609 cites W2004221387 @default.
• W3048683609 cites W2004804925 @default.
• W3048683609 cites W2011524380 @default.
• W3048683609 cites W2019171596 @default.
• W3048683609 cites W2025259772 @default.
• W3048683609 cites W2041216347 @default.
• W3048683609 cites W2043620899 @default.
• W3048683609 cites W2045273788 @default.
• W3048683609 cites W2045776501 @default.
• W3048683609 cites W2070526394 @default.
• W3048683609 cites W2083641726 @default.
• W3048683609 cites W2096662041 @default.
• W3048683609 cites W2117476815 @default.
• W3048683609 cites W2136280424 @default.
• W3048683609 cites W2141860100 @default.
• W3048683609 cites W2146122315 @default.
• W3048683609 cites W2159937805 @default.
• W3048683609 cites W2161444488 @default.
• W3048683609 cites W2164317031 @default.
• W3048683609 cites W2167953950 @default.
• W3048683609 cites W2168383912 @default.
• W3048683609 cites W2226973512 @default.
• W3048683609 cites W2279882281 @default.
• W3048683609 cites W2280072156 @default.
• W3048683609 cites W2316296578 @default.
• W3048683609 cites W2345614766 @default.
• W3048683609 cites W2461078780 @default.
• W3048683609 cites W2462122250 @default.
• W3048683609 cites W2519108591 @default.
• W3048683609 cites W2520200214 @default.
• W3048683609 cites W2570618306 @default.
• W3048683609 cites W2737805000 @default.
• W3048683609 cites W2739305557 @default.
• W3048683609 cites W2768600953 @default.
• W3048683609 cites W2787812668 @default.
• W3048683609 cites W593598076 @default.
• W3048683609 doi "https://doi.org/10.1002/jcp.29975" @default.
• W3048683609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32780451" @default.
• W3048683609 hasPublicationYear "2020" @default.
• W3048683609 type Work @default.
• W3048683609 sameAs 3048683609 @default.
• W3048683609 citedByCount "23" @default.
• W3048683609 countsByYear W30486836092021 @default.
• W3048683609 countsByYear W30486836092022 @default.
• W3048683609 countsByYear W30486836092023 @default.
• W3048683609 crossrefType "journal-article" @default.
• W3048683609 hasAuthorship W3048683609A5005228021 @default.
• W3048683609 hasAuthorship W3048683609A5007989892 @default.
• W3048683609 hasAuthorship W3048683609A5015579895 @default.
• W3048683609 hasAuthorship W3048683609A5027980950 @default.
• W3048683609 hasAuthorship W3048683609A5029404358 @default.
• W3048683609 hasAuthorship W3048683609A5040462812 @default.
• W3048683609 hasAuthorship W3048683609A5066931842 @default.
• W3048683609 hasAuthorship W3048683609A5069595062 @default.
• W3048683609 hasAuthorship W3048683609A5073466957 @default.
• W3048683609 hasAuthorship W3048683609A5076107662 @default.
• W3048683609 hasAuthorship W3048683609A5079568312 @default.
• W3048683609 hasAuthorship W3048683609A5082156719 @default.
• W3048683609 hasAuthorship W3048683609A5083093401 @default.
• W3048683609 hasAuthorship W3048683609A5085071616 @default.
• W3048683609 hasAuthorship W3048683609A5088408355 @default.
• W3048683609 hasAuthorship W3048683609A5089104361 @default.
• W3048683609 hasAuthorship W3048683609A5090605165 @default.
• W3048683609 hasAuthorship W3048683609A5091753897 @default.
• W3048683609 hasConcept C104317684 @default.
• W3048683609 hasConcept C118131993 @default.
• W3048683609 hasConcept C121608353 @default.

• next