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• W3048684947 endingPage "110446" @default.
• W3048684947 startingPage "110446" @default.
• W3048684947 abstract "The RNA world hypothesis, although a viable one regarding the origin of life on earth, has so far failed to provide a compelling explanation for the synthesis of RNA enzymes from free nucleotides via abiotic processes. To tackle this long-standing problem, we develop a realistic model for the onset of the RNA world, using experimentally determined rates for polymerization reactions. We start with minimal assumptions about the initial state that only requires the presence of short oligomers or just free nucleotides and consider the effects of environmental cycling by dividing a day into a dry, semi-wet and wet phases that are distinguished by the nature of reactions they support. Long polymers, with maximum lengths sometimes exceeding 100 nucleotides, spontaneously emerge due to a combination of non-enzymatic, non-templated polymer extension and template-directed primer extension processes. The former helps in increasing the lengths of RNA strands, whereas the later helps in producing complementary copies of the strands. Strands also undergo hydrolysis in a structure-dependent manner that favour breaking of bonds connecting unpaired nucleotides. We identify the most favourable conditions needed for the emergence of ribozyme and tRNA-like structures and double stranded RNA molecules, classify all RNA strands on the basis of their secondary structures and determine their abundance in the population. Our results indicate that under suitable environmental conditions, non-enzymatic processes would have been sufficient to lead to the emergence of a variety of ribozyme-like molecules with complex secondary structures and potential catalytic functions." @default.
• W3048684947 created "2020-08-18" @default.
• W3048684947 creator A5013257418 @default.
• W3048684947 creator A5031795137 @default.
• W3048684947 creator A5045018479 @default.
• W3048684947 creator A5075023736 @default.
• W3048684947 creator A5037503182 @default.
• W3048684947 date "2020-12-01" @default.
• W3048684947 modified "2023-09-30" @default.
• W3048684947 title "Emergence of ribozyme and tRNA-like structures from mineral-rich muddy pools on prebiotic earth" @default.
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• W3048684947 doi "https://doi.org/10.1016/j.jtbi.2020.110446" @default.
• W3048684947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32798505" @default.
• W3048684947 hasPublicationYear "2020" @default.
• W3048684947 type Work @default.
• W3048684947 sameAs 3048684947 @default.

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