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• W3048687645 abstract "Background & aims While long-term obesity is a well-known risk factor for esophageal adenocarcinoma (ADC), recent weight loss represents a significant concern in esophageal cancer (EC), in relation with dysphagia and disease aggressiveness. These phenomenons may diversely impact the adipose tissue density, suggested in other cancer settings as an important prognostic biomarker. The analysis of body mass composition (BMC) parameters, including adipose tissue attenuation is studied here in a population of EC operated with curative intent. Methods BMC was retrospectively evaluated on Computed-Tomography (CT)-scan images from fluorodeoxyglucose (FDG)-positron-emitting (PET)/CT scans performed as a diagnostic procedure in a cohort of 145 EC patients operated with curative intent The mean subcutaneous (SFD) and visceral fat (VFD) density along with the index (area/height2) (SF index (SFI), VF index (VFI)) were assessed on two adjacent slides at the third lumbar vertebra level by two independent investigators. Overall survival (OS) was calculated from the date of the baseline FDG-PET/CT scan. Results Inter-observer correlations are excellent for all BMC parameters (r = 0.94–0.99). As expected, weight loss is associated with worse outcome. We show that low SFD (HR 0.5 (95% CI: 0.3–0.7), p < 0.001) and low VFD (HR 0.6 (95% CI: 0.4–0.9), p = 0.04) at diagnosis are associated with better OS. In contrast, body mass index (BMI) fails to show any relevance in predicting survival. Conclusions Adipose tissue density is an important prognostic factor in EC." @default.
• W3048687645 created "2020-08-18" @default.
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• W3048687645 date "2020-10-01" @default.
• W3048687645 modified "2023-09-26" @default.
• W3048687645 title "Fat density is a novel prognostic marker in patients with esophageal cancer" @default.
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• W3048687645 doi "https://doi.org/10.1016/j.clnesp.2020.07.007" @default.
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