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• W3048687719 abstract "The UPF3B-dependent branch of the nonsense-mediated RNA decay (NMD) pathway is critical for human cognition. Here, we examined the role of UPF3B in the olfactory system. Single-cell RNA-sequencing (scRNA-seq) analysis demonstrated considerable heterogeneity of olfactory sensory neuron (OSN) cell populations in wild-type (WT) mice, and revealed that UPF3B loss influences specific subsets of these cell populations. UPF3B also regulates the expression of a large cadre of antimicrobial genes in OSNs, and promotes the selection of specific olfactory receptor ( Olfr ) genes for expression in mature OSNs (mOSNs). RNA-seq and Ribotag analyses identified classes of mRNAs expressed and translated at different levels in WT and Upf3b -null mOSNs. Integrating multiple computational approaches, UPF3B-dependent NMD target transcripts that are candidates to mediate the functions of NMD in mOSNs were identified in vivo. Together, our data provides a valuable resource for the olfactory field and insights into the roles of NMD in vivo." @default.
• W3048687719 created "2020-08-18" @default.
• W3048687719 creator A5016038041 @default.
• W3048687719 creator A5022856909 @default.
• W3048687719 creator A5026224234 @default.
• W3048687719 creator A5027685117 @default.
• W3048687719 creator A5028641640 @default.
• W3048687719 creator A5033111028 @default.
• W3048687719 creator A5036144585 @default.
• W3048687719 creator A5045362081 @default.
• W3048687719 creator A5049378216 @default.
• W3048687719 creator A5055585390 @default.
• W3048687719 creator A5065761001 @default.
• W3048687719 creator A5075078070 @default.
• W3048687719 creator A5086933648 @default.
• W3048687719 date "2020-08-10" @default.
• W3048687719 modified "2023-09-27" @default.
• W3048687719 title "The role of the NMD factor UPF3B in olfactory sensory neurons" @default.
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