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• W3048689462 abstract "The purpose of this retrospective cohort study was to determine whether there is a difference in the sensitivity of chest computed tomography (CT) versus 18 F-fluorodeoxyglucose positron emission tomography with low-dose nonenhanced CT ( 18 F-FDG PET/CT or PET/CT) in the detection of distant metastases in head and neck cancer, within a tertiary care setting. Patients with head and neck cancer, and known distant metastases, who underwent both 18 F-FDG PET/CT with integrated low-dose nonenhanced CT and diagnostic chest CT prior to initiation of therapy from 2008 to 2017 were included. Two head and neck radiologists, blinded to all patient information and to each other's readings, reviewed the PET/CT or CT chest images for each patient and identified whether distant metastases were present. No radiologist read both modalities for a single patient. Concordance between imaging modalities was quantitatively analyzed using McNemar's test. 27 patients were included. McNemar's mid p -value analysis showed no significant difference in the detection of distant metastases ( p = .6875). However, PET/CT detected distant metastases in three patients that chest CT did not, while chest CT identified distant metastatic disease in two patients that were negative on PET/CT. While this study did not identify a statistically significant difference in sensitivity, five patients had distant metastases identified on only one of the two modalities. Use of a single modality would have resulted in inaccurate staging in 7–11% of patients in our study. The use of both modalities offers the greatest accuracy when providing stage-adapted oncologic treatment. • Metastases in head and neck cancer (HNC) affect stage-adapted oncologic treatment. • Chest CT and PET/CT don't differ in sensitivity in detecting HNC metastases. • Inaccuracy rate of 7–11% when using one imaging modality to detect HNC metastases. • Should use both modalities in non-resource constrained settings." @default.
• W3048689462 created "2020-08-18" @default.
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• W3048689462 date "2020-11-01" @default.
• W3048689462 modified "2023-09-24" @default.
• W3048689462 title "Choice of imaging modality for pre-treatment staging of head and neck cancer impacts TNM staging" @default.
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• W3048689462 doi "https://doi.org/10.1016/j.amjoto.2020.102662" @default.
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