FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048690535> ?p ?o ?g. }

• W3048690535 endingPage "824" @default.
• W3048690535 startingPage "815" @default.
• W3048690535 abstract "Hydrophobic ion pairing (HIP), a solubility engineering technique in which ionic hydrophilic molecules are paired with a hydrophobic counterion, is an attractive strategy for encapsulating ionic water-soluble species into nanocarriers (NCs). Drug release from NCs containing HIP complexes is sensitive to ionic strength, pH, and drug:counterion charge ratio, but the exact mechanism for this was unknown, as was the underlying microstructure inside the NCs. We hypothesize that HIP complexes arrange into liquid crystalline structures in NC cores and that these structures are responsible for salt- and pH-dependent release.A model hydrophobic ion pair from the cationic antimicrobial peptide polymyxin B sulfate and the anionic counterion sodium oleate is encapsulated into ~100 nm NCs formed using Flash NanoPrecipitation (FNP) and stabilized with an amphiphilic diblock copolymer, poly(caprolactone)-b-poly(ethylene glycol). Internal structures are observed using synchrotron small angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) following NC formulation and are found to vary with polymyxin:oleate charge ratio. In vitro drug release is also measured with changes in pH and two charge ratio.For a formulation containing a four-fold charge excess of oleate relative to polymyxin, internal structures rearranged from a lamellar phase into an inverse hexagonal phase. The hexagonal phase formation corresponds to a greatly reduced rate of polymyxin release, suggesting that the polymyxin was incorporated into the center of hexagonally-packed rods. When release tests were repeated using phosphate-buffered saline (PBS) at pH 2.0 to ensure protonation of the oleic acid, all internal structures were eliminated and release occurs much faster than at neutral pH, regardless of charge ratio. These findings shed light on the mechanism behind stimulus-responsive drug release from systems containing hydrophobic ion pairs and enable the rational design of controlled-release formulations by manipulating the formation and dynamics of liquid crystalline phases inside NCs." @default.
• W3048690535 created "2020-08-18" @default.
• W3048690535 creator A5014084023 @default.
• W3048690535 creator A5017915086 @default.
• W3048690535 creator A5044703855 @default.
• W3048690535 creator A5054338352 @default.
• W3048690535 creator A5061360788 @default.
• W3048690535 creator A5066756608 @default.
• W3048690535 date "2021-01-01" @default.
• W3048690535 modified "2023-10-10" @default.
• W3048690535 title "Internal liquid crystal structures in nanocarriers containing drug hydrophobic ion pairs dictate drug release" @default.
• W3048690535 cites W1580991720 @default.
• W3048690535 cites W1969839162 @default.
• W3048690535 cites W1980732767 @default.
• W3048690535 cites W1981657842 @default.
• W3048690535 cites W1988287386 @default.
• W3048690535 cites W1993278004 @default.
• W3048690535 cites W2021426573 @default.
• W3048690535 cites W2041103640 @default.
• W3048690535 cites W2069488861 @default.
• W3048690535 cites W2079723488 @default.
• W3048690535 cites W2083557320 @default.
• W3048690535 cites W2100719274 @default.
• W3048690535 cites W2118623650 @default.
• W3048690535 cites W2143043544 @default.
• W3048690535 cites W2198086793 @default.
• W3048690535 cites W2285408387 @default.
• W3048690535 cites W2309694234 @default.
• W3048690535 cites W2313640741 @default.
• W3048690535 cites W2340985297 @default.
• W3048690535 cites W2515278375 @default.
• W3048690535 cites W2534889487 @default.
• W3048690535 cites W2563063606 @default.
• W3048690535 cites W2741600854 @default.
• W3048690535 cites W2772253469 @default.
• W3048690535 cites W2772413524 @default.
• W3048690535 cites W2910019055 @default.
• W3048690535 cites W2913709367 @default.
• W3048690535 cites W2940694051 @default.
• W3048690535 cites W2978421255 @default.
• W3048690535 cites W2983360509 @default.
• W3048690535 doi "https://doi.org/10.1016/j.jcis.2020.08.045" @default.
• W3048690535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32911422" @default.
• W3048690535 hasPublicationYear "2021" @default.
• W3048690535 type Work @default.
• W3048690535 sameAs 3048690535 @default.
• W3048690535 citedByCount "12" @default.
• W3048690535 countsByYear W30486905352021 @default.
• W3048690535 countsByYear W30486905352022 @default.
• W3048690535 countsByYear W30486905352023 @default.
• W3048690535 crossrefType "journal-article" @default.
• W3048690535 hasAuthorship W3048690535A5014084023 @default.
• W3048690535 hasAuthorship W3048690535A5017915086 @default.
• W3048690535 hasAuthorship W3048690535A5044703855 @default.
• W3048690535 hasAuthorship W3048690535A5054338352 @default.
• W3048690535 hasAuthorship W3048690535A5061360788 @default.
• W3048690535 hasAuthorship W3048690535A5066756608 @default.
• W3048690535 hasBestOaLocation W30486905351 @default.
• W3048690535 hasConcept C120665830 @default.
• W3048690535 hasConcept C121332964 @default.
• W3048690535 hasConcept C127413603 @default.
• W3048690535 hasConcept C131888329 @default.
• W3048690535 hasConcept C145148216 @default.
• W3048690535 hasConcept C178790620 @default.
• W3048690535 hasConcept C18150654 @default.
• W3048690535 hasConcept C185592680 @default.
• W3048690535 hasConcept C191486275 @default.
• W3048690535 hasConcept C2777516009 @default.
• W3048690535 hasConcept C2779820397 @default.
• W3048690535 hasConcept C34814092 @default.
• W3048690535 hasConcept C42360764 @default.
• W3048690535 hasConcept C8010536 @default.
• W3048690535 hasConceptScore W3048690535C120665830 @default.
• W3048690535 hasConceptScore W3048690535C121332964 @default.
• W3048690535 hasConceptScore W3048690535C127413603 @default.
• W3048690535 hasConceptScore W3048690535C131888329 @default.
• W3048690535 hasConceptScore W3048690535C145148216 @default.
• W3048690535 hasConceptScore W3048690535C178790620 @default.
• W3048690535 hasConceptScore W3048690535C18150654 @default.
• W3048690535 hasConceptScore W3048690535C185592680 @default.
• W3048690535 hasConceptScore W3048690535C191486275 @default.
• W3048690535 hasConceptScore W3048690535C2777516009 @default.
• W3048690535 hasConceptScore W3048690535C2779820397 @default.
• W3048690535 hasConceptScore W3048690535C34814092 @default.
• W3048690535 hasConceptScore W3048690535C42360764 @default.
• W3048690535 hasConceptScore W3048690535C8010536 @default.
• W3048690535 hasFunder F4320306076 @default.
• W3048690535 hasLocation W30486905351 @default.
• W3048690535 hasLocation W30486905352 @default.
• W3048690535 hasOpenAccess W3048690535 @default.
• W3048690535 hasPrimaryLocation W30486905351 @default.
• W3048690535 hasRelatedWork W1973200142 @default.
• W3048690535 hasRelatedWork W2060788024 @default.
• W3048690535 hasRelatedWork W2131873609 @default.
• W3048690535 hasRelatedWork W2313116548 @default.
• W3048690535 hasRelatedWork W2748952813 @default.
• W3048690535 hasRelatedWork W2754489696 @default.
• W3048690535 hasRelatedWork W2891778907 @default.

• next