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• W3048694039 abstract "BackgroundA growing body of literature addresses the possible long-term cognitive effects of anaesthetics, but no study has delineated the normal trajectory of neural recovery attributable to anaesthesia alone in adults. We obtained resting-state functional MRI scans on 72 healthy human volunteers between ages 40 and 80 (median: 59) yr before, during, and after general anaesthesia with sevoflurane, in the absence of surgery, as part of a larger study on cognitive function postanaesthesia.MethodsRegion-of-interest analysis, independent component analysis, and seed-to-voxel analysis were used to characterise resting-state functional connectivity and to differentiate between correlated and anticorrelated connectivity before, during, and after general anaesthesia.ResultsWhilst positively correlated functional connectivity remained essentially unchanged across these perianaesthetic states, anticorrelated functional connectivity decreased globally by 35% 1 h after emergence from general anaesthesia compared with baseline, as seen by the region-of-interest analysis. This decrease corresponded to a consistent reduction in expression of canonical resting-state networks, as seen by independent component analysis. All measures returned to baseline 1 day later.ConclusionsThe normal perianaesthesia trajectory of resting-state connectivity in healthy adults is characterised by a transient global reduction in anticorrelated activity shortly after emergence from anaesthesia that returns to baseline by the following day.Clinical trial registrationNCT02275026." @default.
• W3048694039 created "2020-08-18" @default.
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• W3048694039 date "2020-10-01" @default.
• W3048694039 modified "2023-09-29" @default.
• W3048694039 title "Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations" @default.
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• W3048694039 doi "https://doi.org/10.1016/j.bja.2020.06.058" @default.
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