FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048694879> ?p ?o ?g. }

• W3048694879 endingPage "2430" @default.
• W3048694879 startingPage "2430" @default.
• W3048694879 abstract "Punicalagin (PU), a polyphenol extracted from pomegranate (Punica granatum) husk is proven to have anti-cancer effects on different types of cancer including colorectal cancer (CRC). Its role in modulating endogenous protein as a means of eliciting its anti-cancer effects, however, has not been explored to date. Hence, this study aimed to investigate the role of PU in modulating the interplay between apoptosis and autophagy by regulating Annexin A1 (Anx-A1) expression in HCT 116 colorectal adenocarcinoma cells. In the study, selective cytotoxicity, pro-apoptotic, autophagic and Anx-A1 downregulating properties of PU were shown which indicate therapeutic potential that this polyphenol has against CRC. Autophagy flux analysis via flow cytometry showed significant autophagosomes degradation in treated cells, proving the involvement of autophagy. Proteome profiling of 35 different proteins in the presence and absence of Anx-A1 antagonists in PU-treated cells demonstrated a complex interplay that happens between apoptosis and autophagy that suggests the possible simultaneous induction and inhibition of these two cell death mechanisms by PU. Overall, this study suggests that PU induces autophagy while maintaining basal level of apoptosis as the main mechanisms of cytotoxicity via the modulation of Anx-A1 expression in HCT 116 cells, and thus has a promising translational potential." @default.
• W3048694879 created "2020-08-18" @default.
• W3048694879 creator A5023879533 @default.
• W3048694879 creator A5029862139 @default.
• W3048694879 creator A5058116774 @default.
• W3048694879 creator A5072078117 @default.
• W3048694879 date "2020-08-13" @default.
• W3048694879 modified "2023-10-18" @default.
• W3048694879 title "Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer" @default.
• W3048694879 cites W135912374 @default.
• W3048694879 cites W1497251274 @default.
• W3048694879 cites W1738287572 @default.
• W3048694879 cites W1757407923 @default.
• W3048694879 cites W1969324270 @default.
• W3048694879 cites W1970469265 @default.
• W3048694879 cites W1982160406 @default.
• W3048694879 cites W2008757142 @default.
• W3048694879 cites W2010787519 @default.
• W3048694879 cites W2017855147 @default.
• W3048694879 cites W2018347389 @default.
• W3048694879 cites W2021907631 @default.
• W3048694879 cites W2025336062 @default.
• W3048694879 cites W2034132952 @default.
• W3048694879 cites W2057482668 @default.
• W3048694879 cites W2085613922 @default.
• W3048694879 cites W2093095159 @default.
• W3048694879 cites W2101571252 @default.
• W3048694879 cites W2109840033 @default.
• W3048694879 cites W2131966528 @default.
• W3048694879 cites W2135957982 @default.
• W3048694879 cites W2148200419 @default.
• W3048694879 cites W2150027419 @default.
• W3048694879 cites W2159372512 @default.
• W3048694879 cites W2292766005 @default.
• W3048694879 cites W2473796523 @default.
• W3048694879 cites W2555257806 @default.
• W3048694879 cites W2735075858 @default.
• W3048694879 cites W2735590725 @default.
• W3048694879 cites W2746369737 @default.
• W3048694879 cites W2754768114 @default.
• W3048694879 cites W2808982442 @default.
• W3048694879 cites W2884425253 @default.
• W3048694879 cites W2890688690 @default.
• W3048694879 cites W2909349495 @default.
• W3048694879 doi "https://doi.org/10.3390/nu12082430" @default.
• W3048694879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7468705" @default.
• W3048694879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32823596" @default.
• W3048694879 hasPublicationYear "2020" @default.
• W3048694879 type Work @default.
• W3048694879 sameAs 3048694879 @default.
• W3048694879 citedByCount "14" @default.
• W3048694879 countsByYear W30486948792021 @default.
• W3048694879 countsByYear W30486948792022 @default.
• W3048694879 countsByYear W30486948792023 @default.
• W3048694879 crossrefType "journal-article" @default.
• W3048694879 hasAuthorship W3048694879A5023879533 @default.
• W3048694879 hasAuthorship W3048694879A5029862139 @default.
• W3048694879 hasAuthorship W3048694879A5058116774 @default.
• W3048694879 hasAuthorship W3048694879A5072078117 @default.
• W3048694879 hasBestOaLocation W30486948791 @default.
• W3048694879 hasConcept C109316439 @default.
• W3048694879 hasConcept C121608353 @default.
• W3048694879 hasConcept C153911025 @default.
• W3048694879 hasConcept C185592680 @default.
• W3048694879 hasConcept C190283241 @default.
• W3048694879 hasConcept C202751555 @default.
• W3048694879 hasConcept C203522944 @default.
• W3048694879 hasConcept C2780670749 @default.
• W3048694879 hasConcept C31573885 @default.
• W3048694879 hasConcept C502942594 @default.
• W3048694879 hasConcept C526805850 @default.
• W3048694879 hasConcept C54355233 @default.
• W3048694879 hasConcept C553184892 @default.
• W3048694879 hasConcept C55493867 @default.
• W3048694879 hasConcept C86803240 @default.
• W3048694879 hasConcept C88634738 @default.
• W3048694879 hasConcept C95444343 @default.
• W3048694879 hasConcept C96232424 @default.
• W3048694879 hasConceptScore W3048694879C109316439 @default.
• W3048694879 hasConceptScore W3048694879C121608353 @default.
• W3048694879 hasConceptScore W3048694879C153911025 @default.
• W3048694879 hasConceptScore W3048694879C185592680 @default.
• W3048694879 hasConceptScore W3048694879C190283241 @default.
• W3048694879 hasConceptScore W3048694879C202751555 @default.
• W3048694879 hasConceptScore W3048694879C203522944 @default.
• W3048694879 hasConceptScore W3048694879C2780670749 @default.
• W3048694879 hasConceptScore W3048694879C31573885 @default.
• W3048694879 hasConceptScore W3048694879C502942594 @default.
• W3048694879 hasConceptScore W3048694879C526805850 @default.
• W3048694879 hasConceptScore W3048694879C54355233 @default.
• W3048694879 hasConceptScore W3048694879C553184892 @default.
• W3048694879 hasConceptScore W3048694879C55493867 @default.
• W3048694879 hasConceptScore W3048694879C86803240 @default.
• W3048694879 hasConceptScore W3048694879C88634738 @default.
• W3048694879 hasConceptScore W3048694879C95444343 @default.
• W3048694879 hasConceptScore W3048694879C96232424 @default.
• W3048694879 hasIssue "8" @default.
• W3048694879 hasLocation W30486948791 @default.

• next