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- W3048698242 abstract "Aim: This study aimed to identify long noncoding RNAs (lncRNAs) with potential to be prognostic biomarkers of hepatocellular carcinoma (HCC) by analyzing copy number alterations (CNAs). Methods: RNA Sequencing data of 369 HCC patients was downloaded from The Cancer Genome Atlas database and analyzed with a series of systematic bioinformatics methods. Results: LncRNA-CNA association analysis revealed that many lncRNAs were located in sites frequently amplified or deleted. Three upregulated lncRNAs (LINC00689, SNHG20 and MAFG-AS1) with copy amplification and one downregulated lncRNA TMEM220-AS1 with copy deletion were associated with poor prognosis of HCC. Conclusion: This study reveals that differentially expressed lncRNAs correlate with CNAs in HCC. Moreover, the differentially expressed lncRNAs and their copy amplification/deletions could be promising prognostic biomarkers of HCC." @default.
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- W3048698242 date "2020-08-01" @default.
- W3048698242 modified "2023-10-07" @default.
- W3048698242 title "Identification of prognostic biomarkers of hepatocellular carcinoma via long noncoding RNA expression and copy number alterations" @default.
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- W3048698242 doi "https://doi.org/10.2217/epi-2019-0385" @default.
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