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• W3048703159 abstract "Abstract Morphogen signaling proteins disperse across tissues to activate signal transduction in target cells. We investigated dispersion of Hedgehog (Hh), Wingless (Wg), and Bone morphogenic protein homolog Decapentaplegic (Dpp) in the Drosophila wing imaginal disc, and found that delivery to targets is regulated. Cells take up <5% Hh produced, and neither amounts taken up nor extent of signaling changes under conditions of Hh production from 50-200% normal amounts. Similarly, cells take up <25% Wg produced, and variation in Wg production from 50-700% normal has no effect on amounts taken up or signaling. Similar properties were observed for Dpp. Wing disc-produced Hh signals to disc-associated tracheal and myoblast as well as an approximately equal number of disc cells, but the extent of signaling in the disc is unaffected by the presence or absence of the tracheal cells and myoblasts. These findings show that target cells do not take up signaling proteins from a common pool and that both the amount and destination of delivered morphogens are regulated.. Summary The extent of Hh, Wg, and Dpp signaling is independent of the amount of signal produced or the number of recipient cells." @default.
• W3048703159 created "2020-08-18" @default.
• W3048703159 creator A5011046135 @default.
• W3048703159 creator A5014636845 @default.
• W3048703159 date "2020-08-13" @default.
• W3048703159 modified "2023-10-15" @default.
• W3048703159 title "Regulated delivery controls Drosophila Hedgehog, Wingless and Decapentaplegic signaling" @default.
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• W3048703159 doi "https://doi.org/10.1101/2020.08.12.247759" @default.
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