Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048704443> ?p ?o ?g. }
- W3048704443 abstract "Developmental studies revealed fundamental principles on how organ size and function is achieved, but less is known about organ adaptation to new physiological demands. In fruit flies, juvenile hormone (JH) induces intestinal stem cell (ISC) driven absorptive epithelial expansion balancing energy uptake with increased energy demands of pregnancy. Here, we show 20-Hydroxy-Ecdysone (20HE)-signaling controlling organ homeostasis with physiological and pathological implications. Upon mating, 20HE titer in ovaries and hemolymph are increased and act on nearby midgut progenitors inducing Ecdysone-induced-protein-75B (Eip75B). Strikingly, the PPARγ -homologue Eip75B drives ISC daughter cells towards absorptive enterocyte lineage ensuring epithelial growth. To our knowledge, this is the first time a systemic hormone is shown to direct local stem cell fate decisions. Given the protective, but mechanistically unclear role of steroid hormones in female colorectal cancer patients, our findings suggest a tumor-suppressive role for steroidal signaling by promoting postmitotic fate when local signaling is deteriorated." @default.
- W3048704443 created "2020-08-18" @default.
- W3048704443 creator A5019192461 @default.
- W3048704443 creator A5026868197 @default.
- W3048704443 creator A5028965426 @default.
- W3048704443 creator A5080927444 @default.
- W3048704443 creator A5084627362 @default.
- W3048704443 date "2020-08-10" @default.
- W3048704443 modified "2023-10-18" @default.
- W3048704443 title "Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila" @default.
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