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- W3048705463 abstract "Unique expression patterns of the 5' HoxA genes are associated with the evolution and development of novel features including claspers in cartilaginous fishes, modified pectoral fins in batoids, and the yolk sac extension in Cypriniformes. Here, we demonstrate a role for HoxA11a and HoxA13a in demarcating the hindgut in fishes of the family Gobiidae, including a novel sphincter called the intestinal rectal sphincter (IRS). Disruption of 5' HoxA expression, via manipulation of retinoic acid signaling, results in failure of the IRS and/or vent to develop. Furthermore, exposure to HoxA disruptors alters 5' HoxA expression, in association with developmental phenotypes, demonstrating a functional link between 5' HoxA expression and development of a novel feature in the bluebanded goby, Lythrypnus dalli." @default.
- W3048705463 created "2020-08-18" @default.
- W3048705463 creator A5021740530 @default.
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- W3048705463 date "2020-08-10" @default.
- W3048705463 modified "2023-10-14" @default.
- W3048705463 title "The role of the 5′ HoxA genes in the development of the hindgut, vent, and a novel sphincter in a derived teleost (bluebanded goby, <i>Lythrypnus dalli</i>)" @default.
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- W3048705463 doi "https://doi.org/10.1002/jez.b.22982" @default.
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