FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048728071> ?p ?o ?g. }

• W3048728071 endingPage "265" @default.
• W3048728071 startingPage "258" @default.
• W3048728071 abstract "Abstract Background ASPirin in Reducing Events in the Elderly, a randomized, double-blind, placebo-controlled trial of daily low-dose aspirin (100 mg) in older adults, showed an increase in all-cause mortality, primarily due to cancer. In contrast, prior randomized controlled trials, mainly involving younger individuals, demonstrated a delayed cancer benefit with aspirin. We now report a detailed analysis of cancer incidence and mortality. Methods 19 114 Australian and US community-dwelling participants aged 70 years and older (US minorities 65 years and older) without cardiovascular disease, dementia, or physical disability were randomly assigned and followed for a median of 4.7 years. Fatal and nonfatal cancer events, a prespecified secondary endpoint, were adjudicated based on clinical records. Results 981 cancer events occurred in the aspirin and 952 in the placebo groups. There was no statistically significant difference between groups for all incident cancers (hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 0.95 to 1.14), hematological cancer (HR = 0.98, 95% CI = 0.73 to 1.30), or all solid cancers (HR = 1.05, 95% CI = 0.95 to 1.15), including by specific tumor type. However, aspirin was associated with an increased risk of incident cancer that had metastasized (HR = 1.19, 95% CI = 1.00 to 1.43) or was stage 4 at diagnosis (HR = 1.22, 95% CI = 1.02 to 1.45), and with higher risk of death for cancers that presented at stages 3 (HR = 2.11, 95% CI = 1.03 to 4.33) or 4 (HR = 1.31, 95% CI = 1.04 to 1.64). Conclusions In older adults, aspirin treatment had an adverse effect on later stages of cancer evolution. These findings suggest that in older persons, aspirin may accelerate the progression of cancer and, thus, suggest caution with its use in this age group." @default.
• W3048728071 created "2020-08-18" @default.
• W3048728071 creator A5005785019 @default.
• W3048728071 creator A5008173055 @default.
• W3048728071 creator A5008765045 @default.
• W3048728071 creator A5012502220 @default.
• W3048728071 creator A5022309484 @default.
• W3048728071 creator A5023911162 @default.
• W3048728071 creator A5026470588 @default.
• W3048728071 creator A5034083482 @default.
• W3048728071 creator A5041942546 @default.
• W3048728071 creator A5042187237 @default.
• W3048728071 creator A5044983885 @default.
• W3048728071 creator A5046655313 @default.
• W3048728071 creator A5049889117 @default.
• W3048728071 creator A5050901838 @default.
• W3048728071 creator A5054368962 @default.
• W3048728071 creator A5057379795 @default.
• W3048728071 creator A5062551704 @default.
• W3048728071 creator A5066787545 @default.
• W3048728071 creator A5067186924 @default.
• W3048728071 creator A5068463698 @default.
• W3048728071 creator A5068835941 @default.
• W3048728071 creator A5069190409 @default.
• W3048728071 creator A5071210112 @default.
• W3048728071 creator A5071496344 @default.
• W3048728071 creator A5075700550 @default.
• W3048728071 creator A5082697210 @default.
• W3048728071 creator A5090545021 @default.
• W3048728071 date "2020-08-11" @default.
• W3048728071 modified "2023-10-17" @default.
• W3048728071 title "Effect of Aspirin on Cancer Incidence and Mortality in Older Adults" @default.
• W3048728071 cites W1533850659 @default.
• W3048728071 cites W1987698903 @default.
• W3048728071 cites W1992513311 @default.
• W3048728071 cites W1995252424 @default.
• W3048728071 cites W1999571408 @default.
• W3048728071 cites W2060437807 @default.
• W3048728071 cites W2102937816 @default.
• W3048728071 cites W2111175587 @default.
• W3048728071 cites W2123042275 @default.
• W3048728071 cites W2144535782 @default.
• W3048728071 cites W2151036184 @default.
• W3048728071 cites W2151606046 @default.
• W3048728071 cites W2251113869 @default.
• W3048728071 cites W2331422116 @default.
• W3048728071 cites W2332455909 @default.
• W3048728071 cites W2376159193 @default.
• W3048728071 cites W2588728606 @default.
• W3048728071 cites W2767842448 @default.
• W3048728071 cites W2779114318 @default.
• W3048728071 cites W2803457619 @default.
• W3048728071 cites W2884727639 @default.
• W3048728071 cites W2889884522 @default.
• W3048728071 cites W2891412296 @default.
• W3048728071 cites W2899755710 @default.
• W3048728071 cites W2901981972 @default.
• W3048728071 cites W2922024285 @default.
• W3048728071 cites W2945386138 @default.
• W3048728071 cites W2949836841 @default.
• W3048728071 cites W2969694562 @default.
• W3048728071 doi "https://doi.org/10.1093/jnci/djaa114" @default.
• W3048728071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7936068" @default.
• W3048728071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32778876" @default.
• W3048728071 hasPublicationYear "2020" @default.
• W3048728071 type Work @default.
• W3048728071 sameAs 3048728071 @default.
• W3048728071 citedByCount "72" @default.
• W3048728071 countsByYear W30487280712020 @default.
• W3048728071 countsByYear W30487280712021 @default.
• W3048728071 countsByYear W30487280712022 @default.
• W3048728071 countsByYear W30487280712023 @default.
• W3048728071 crossrefType "journal-article" @default.
• W3048728071 hasAuthorship W3048728071A5005785019 @default.
• W3048728071 hasAuthorship W3048728071A5008173055 @default.
• W3048728071 hasAuthorship W3048728071A5008765045 @default.
• W3048728071 hasAuthorship W3048728071A5012502220 @default.
• W3048728071 hasAuthorship W3048728071A5022309484 @default.
• W3048728071 hasAuthorship W3048728071A5023911162 @default.
• W3048728071 hasAuthorship W3048728071A5026470588 @default.
• W3048728071 hasAuthorship W3048728071A5034083482 @default.
• W3048728071 hasAuthorship W3048728071A5041942546 @default.
• W3048728071 hasAuthorship W3048728071A5042187237 @default.
• W3048728071 hasAuthorship W3048728071A5044983885 @default.
• W3048728071 hasAuthorship W3048728071A5046655313 @default.
• W3048728071 hasAuthorship W3048728071A5049889117 @default.
• W3048728071 hasAuthorship W3048728071A5050901838 @default.
• W3048728071 hasAuthorship W3048728071A5054368962 @default.
• W3048728071 hasAuthorship W3048728071A5057379795 @default.
• W3048728071 hasAuthorship W3048728071A5062551704 @default.
• W3048728071 hasAuthorship W3048728071A5066787545 @default.
• W3048728071 hasAuthorship W3048728071A5067186924 @default.
• W3048728071 hasAuthorship W3048728071A5068463698 @default.
• W3048728071 hasAuthorship W3048728071A5068835941 @default.
• W3048728071 hasAuthorship W3048728071A5069190409 @default.
• W3048728071 hasAuthorship W3048728071A5071210112 @default.
• W3048728071 hasAuthorship W3048728071A5071496344 @default.
• W3048728071 hasAuthorship W3048728071A5075700550 @default.

• next