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- W3048746735 endingPage "5786" @default.
- W3048746735 startingPage "5786" @default.
- W3048746735 abstract "Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial–mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in “liquid” human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota." @default.
- W3048746735 created "2020-08-18" @default.
- W3048746735 creator A5010111759 @default.
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- W3048746735 creator A5027551885 @default.
- W3048746735 creator A5069404918 @default.
- W3048746735 creator A5089717996 @default.
- W3048746735 date "2020-08-12" @default.
- W3048746735 modified "2023-10-11" @default.
- W3048746735 title "Microbiota-Derived Metabolites in Tumor Progression and Metastasis" @default.
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