FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048748063> ?p ?o ?g. }

• W3048748063 endingPage "114197" @default.
• W3048748063 startingPage "114197" @default.
• W3048748063 abstract "Hepatic estrogen sulfotransferase (SULT1E1), the enzyme that inactivates estrogen, regulates metabolic estrogen homeostasis. Here, we have demonstrated how nuclear receptor PXR regulated the SULT1E1 gene in response to glucose in human hepatoma-derived cells and in response to fasting in mouse livers. The SULT1E1 gene was activated by a nuclear receptor HNF4α-RORα complex binding on an upstream enhancer of the SULT1E1 promoter in cells cultured in high glucose medium (Hu and Negishi, 2020). The SULT1E1 gene was repressed in cells cultured in low glucose medium, in which PXR was phosphorylated at Ser350 by vaccinia virus-related kinase 1. Phosphorylated PXR interacted with this complex, retaining HNF4α on and dissociating RORα from the enhancer as a phosphorylated PXR complex. Therefore, in response to low glucose, phosphorylated PXR transduced a low glucose signal to repress the SULT1E1 gene in cells. Hepatic Sult1e1 mRNA was induced in PXR wild type (WT) male mice in response to fasting, whereas this induction was synergistically increased in phosphorylation-blocking PXR Ser347Ala (Ser350 in human) KI males over that observed in PXR WT males. As phosphorylated PXR repressed the Sult1e1 gene, it increased its binding to the Sult1e1 promoter in WT males. The absence of phosphorylated PXR resulted in the synergistic activation of the Sult1e1 gene in PXR KI males. Apparently, phosphorylated PXR functioned as a transcriptional repressor to the SULT1E1/Sult1e1 gene in human liver cells and mouse livers." @default.
• W3048748063 created "2020-08-18" @default.
• W3048748063 creator A5081935894 @default.
• W3048748063 creator A5086376220 @default.
• W3048748063 creator A5089629096 @default.
• W3048748063 date "2020-10-01" @default.
• W3048748063 modified "2023-09-24" @default.
• W3048748063 title "PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers" @default.
• W3048748063 cites W1971990705 @default.
• W3048748063 cites W1977788134 @default.
• W3048748063 cites W1978213778 @default.
• W3048748063 cites W1981873124 @default.
• W3048748063 cites W2001968599 @default.
• W3048748063 cites W2009838390 @default.
• W3048748063 cites W2021444563 @default.
• W3048748063 cites W2026231235 @default.
• W3048748063 cites W2026383483 @default.
• W3048748063 cites W2035000881 @default.
• W3048748063 cites W2057743013 @default.
• W3048748063 cites W2060551064 @default.
• W3048748063 cites W2060911425 @default.
• W3048748063 cites W2063203910 @default.
• W3048748063 cites W2064176291 @default.
• W3048748063 cites W2067844668 @default.
• W3048748063 cites W2073950955 @default.
• W3048748063 cites W2082557460 @default.
• W3048748063 cites W2084720330 @default.
• W3048748063 cites W2094806430 @default.
• W3048748063 cites W2099500855 @default.
• W3048748063 cites W2139144456 @default.
• W3048748063 cites W2141759136 @default.
• W3048748063 cites W2150367899 @default.
• W3048748063 cites W2151308509 @default.
• W3048748063 cites W2155831585 @default.
• W3048748063 cites W2155882942 @default.
• W3048748063 cites W2168654583 @default.
• W3048748063 cites W2404601696 @default.
• W3048748063 cites W2408019634 @default.
• W3048748063 cites W2580035316 @default.
• W3048748063 cites W2733862365 @default.
• W3048748063 cites W2743274282 @default.
• W3048748063 cites W2751589694 @default.
• W3048748063 cites W2755043893 @default.
• W3048748063 cites W2808027779 @default.
• W3048748063 cites W2884716689 @default.
• W3048748063 cites W3000786100 @default.
• W3048748063 cites W3012156559 @default.
• W3048748063 cites W3012890711 @default.
• W3048748063 cites W3014651456 @default.
• W3048748063 cites W3045206561 @default.
• W3048748063 cites W783557619 @default.
• W3048748063 doi "https://doi.org/10.1016/j.bcp.2020.114197" @default.
• W3048748063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32798464" @default.
• W3048748063 hasPublicationYear "2020" @default.
• W3048748063 type Work @default.
• W3048748063 sameAs 3048748063 @default.
• W3048748063 citedByCount "9" @default.
• W3048748063 countsByYear W30487480632021 @default.
• W3048748063 countsByYear W30487480632022 @default.
• W3048748063 countsByYear W30487480632023 @default.
• W3048748063 crossrefType "journal-article" @default.
• W3048748063 hasAuthorship W3048748063A5081935894 @default.
• W3048748063 hasAuthorship W3048748063A5086376220 @default.
• W3048748063 hasAuthorship W3048748063A5089629096 @default.
• W3048748063 hasConcept C104317684 @default.
• W3048748063 hasConcept C111936080 @default.
• W3048748063 hasConcept C11960822 @default.
• W3048748063 hasConcept C126322002 @default.
• W3048748063 hasConcept C132040763 @default.
• W3048748063 hasConcept C134018914 @default.
• W3048748063 hasConcept C150194340 @default.
• W3048748063 hasConcept C153911025 @default.
• W3048748063 hasConcept C165864922 @default.
• W3048748063 hasConcept C55493867 @default.
• W3048748063 hasConcept C63932345 @default.
• W3048748063 hasConcept C71924100 @default.
• W3048748063 hasConcept C86339819 @default.
• W3048748063 hasConcept C86803240 @default.
• W3048748063 hasConcept C95444343 @default.
• W3048748063 hasConceptScore W3048748063C104317684 @default.
• W3048748063 hasConceptScore W3048748063C111936080 @default.
• W3048748063 hasConceptScore W3048748063C11960822 @default.
• W3048748063 hasConceptScore W3048748063C126322002 @default.
• W3048748063 hasConceptScore W3048748063C132040763 @default.
• W3048748063 hasConceptScore W3048748063C134018914 @default.
• W3048748063 hasConceptScore W3048748063C150194340 @default.
• W3048748063 hasConceptScore W3048748063C153911025 @default.
• W3048748063 hasConceptScore W3048748063C165864922 @default.
• W3048748063 hasConceptScore W3048748063C55493867 @default.
• W3048748063 hasConceptScore W3048748063C63932345 @default.
• W3048748063 hasConceptScore W3048748063C71924100 @default.
• W3048748063 hasConceptScore W3048748063C86339819 @default.
• W3048748063 hasConceptScore W3048748063C86803240 @default.
• W3048748063 hasConceptScore W3048748063C95444343 @default.
• W3048748063 hasLocation W30487480631 @default.
• W3048748063 hasOpenAccess W3048748063 @default.
• W3048748063 hasPrimaryLocation W30487480631 @default.
• W3048748063 hasRelatedWork W2002387694 @default.

• next