Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048751077> ?p ?o ?g. }
- W3048751077 endingPage "105510" @default.
- W3048751077 startingPage "105510" @default.
- W3048751077 abstract "The vital enzyme O-linked β-N-acetylglucosamine transferase (OGT) catalyzes the O-GlcNAcylation of intracellular proteins coupling the metabolic status to cellular signaling and transcription pathways. Aberrant levels of O-GlcNAc and OGT have been linked to metabolic diseases as cancer and diabetes. Here, a new series of peptidomimetic OGT inhibitors was identified highlighting the compound LQMed 330, which presented better IC50 compared to the most potent inhibitors found in the literature. Molecular modeling study of selected inhibitors into the OGT binding site provided insight into the behavior by which these compounds interact with the enzyme. The results obtained in this study provided new perspectives on the design and synthesis of highly specific OGT inhibitors." @default.
- W3048751077 created "2020-08-18" @default.
- W3048751077 creator A5012760924 @default.
- W3048751077 creator A5020994299 @default.
- W3048751077 creator A5034989642 @default.
- W3048751077 creator A5054798638 @default.
- W3048751077 creator A5057768672 @default.
- W3048751077 creator A5064636021 @default.
- W3048751077 creator A5067395751 @default.
- W3048751077 creator A5078023227 @default.
- W3048751077 creator A5082218753 @default.
- W3048751077 creator A5087633101 @default.
- W3048751077 creator A5088361436 @default.
- W3048751077 creator A5090531904 @default.
- W3048751077 date "2020-11-01" @default.
- W3048751077 modified "2023-10-01" @default.
- W3048751077 title "Biological evaluation and molecular modeling of peptidomimetic compounds as inhibitors for O-GlcNAc transferase (OGT)" @default.
- W3048751077 cites W1975320495 @default.
- W3048751077 cites W1981021420 @default.
- W3048751077 cites W1998906741 @default.
- W3048751077 cites W2005886610 @default.
- W3048751077 cites W2008312146 @default.
- W3048751077 cites W2008832722 @default.
- W3048751077 cites W2030718808 @default.
- W3048751077 cites W2031957765 @default.
- W3048751077 cites W2032258751 @default.
- W3048751077 cites W2035687084 @default.
- W3048751077 cites W2041337154 @default.
- W3048751077 cites W2044172327 @default.
- W3048751077 cites W2044688375 @default.
- W3048751077 cites W2047399603 @default.
- W3048751077 cites W2050456292 @default.
- W3048751077 cites W2050775180 @default.
- W3048751077 cites W2052372990 @default.
- W3048751077 cites W2056173710 @default.
- W3048751077 cites W2056602670 @default.
- W3048751077 cites W2057477511 @default.
- W3048751077 cites W2060433756 @default.
- W3048751077 cites W2067174909 @default.
- W3048751077 cites W2068017935 @default.
- W3048751077 cites W2071520055 @default.
- W3048751077 cites W2077973224 @default.
- W3048751077 cites W2080462728 @default.
- W3048751077 cites W2081693079 @default.
- W3048751077 cites W2095472366 @default.
- W3048751077 cites W2105649494 @default.
- W3048751077 cites W2128572087 @default.
- W3048751077 cites W2135732933 @default.
- W3048751077 cites W2144619812 @default.
- W3048751077 cites W2147571602 @default.
- W3048751077 cites W2151970827 @default.
- W3048751077 cites W2160033413 @default.
- W3048751077 cites W2167029191 @default.
- W3048751077 cites W2171268876 @default.
- W3048751077 cites W2208175234 @default.
- W3048751077 cites W2269421555 @default.
- W3048751077 cites W2340673398 @default.
- W3048751077 cites W2550685635 @default.
- W3048751077 cites W2555870966 @default.
- W3048751077 cites W2593436234 @default.
- W3048751077 cites W2733652050 @default.
- W3048751077 cites W2735900143 @default.
- W3048751077 cites W2782629691 @default.
- W3048751077 cites W2799580679 @default.
- W3048751077 cites W2801169841 @default.
- W3048751077 cites W2895737508 @default.
- W3048751077 cites W2911143204 @default.
- W3048751077 cites W2916965102 @default.
- W3048751077 cites W2940601530 @default.
- W3048751077 cites W3024291645 @default.
- W3048751077 doi "https://doi.org/10.1016/j.ejps.2020.105510" @default.
- W3048751077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32801002" @default.
- W3048751077 hasPublicationYear "2020" @default.
- W3048751077 type Work @default.
- W3048751077 sameAs 3048751077 @default.
- W3048751077 citedByCount "24" @default.
- W3048751077 countsByYear W30487510772021 @default.
- W3048751077 countsByYear W30487510772022 @default.
- W3048751077 countsByYear W30487510772023 @default.
- W3048751077 crossrefType "journal-article" @default.
- W3048751077 hasAuthorship W3048751077A5012760924 @default.
- W3048751077 hasAuthorship W3048751077A5020994299 @default.
- W3048751077 hasAuthorship W3048751077A5034989642 @default.
- W3048751077 hasAuthorship W3048751077A5054798638 @default.
- W3048751077 hasAuthorship W3048751077A5057768672 @default.
- W3048751077 hasAuthorship W3048751077A5064636021 @default.
- W3048751077 hasAuthorship W3048751077A5067395751 @default.
- W3048751077 hasAuthorship W3048751077A5078023227 @default.
- W3048751077 hasAuthorship W3048751077A5082218753 @default.
- W3048751077 hasAuthorship W3048751077A5087633101 @default.
- W3048751077 hasAuthorship W3048751077A5088361436 @default.
- W3048751077 hasAuthorship W3048751077A5090531904 @default.
- W3048751077 hasConcept C124790011 @default.
- W3048751077 hasConcept C161019410 @default.
- W3048751077 hasConcept C178910836 @default.
- W3048751077 hasConcept C181199279 @default.
- W3048751077 hasConcept C185592680 @default.
- W3048751077 hasConcept C2776376580 @default.