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• W3048751131 endingPage "3663" @default.
• W3048751131 startingPage "3663" @default.
• W3048751131 abstract "Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies the delivery of modified antisense oligonucleotides by so-called transport oligonucleotides (tON), which are oligodeoxyribonucleotides complementary to asON conjugated with hydrophobic dodecyl moieties. Two types of tONs, bearing at the 5′-end up to three dodecyl residues attached through non-nucleotide inserts (TD series) or anchored directly to internucleotidic phosphate (TP series), were synthesized. tONs with three dodecyl residues efficiently delivered asON to cells without any signs of cytotoxicity and provided a transfection efficacy comparable to that achieved using Lipofectamine 2000. We found that, in the case of tON with three dodecyl residues, some tON/asON duplexes were excreted from the cells within extracellular vesicles at late stages of transfection. We confirmed the high efficacy of the novel and demonstrated that MDR1 mRNA targeted asON delivered by tON with three dodecyl residues significantly reduced the level of P-glycoprotein and increased the sensitivity of KB-8-5 human carcinoma cells to vinblastine. The obtained results demonstrate the efficacy of lipophilic oligonucleotide carriers and shows they are potentially capable of intracellular delivery of any kind of antisense oligonucleotides." @default.
• W3048751131 created "2020-08-18" @default.
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• W3048751131 date "2020-08-11" @default.
• W3048751131 modified "2023-10-06" @default.
• W3048751131 title "Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics" @default.
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• W3048751131 cites W1980870708 @default.
• W3048751131 cites W1981701014 @default.
• W3048751131 cites W1987554430 @default.
• W3048751131 cites W1994293249 @default.
• W3048751131 cites W2002050544 @default.
• W3048751131 cites W2005101585 @default.
• W3048751131 cites W2008541712 @default.
• W3048751131 cites W2018848468 @default.
• W3048751131 cites W2031640807 @default.
• W3048751131 cites W2044935159 @default.
• W3048751131 cites W2058281342 @default.
• W3048751131 cites W2060725600 @default.
• W3048751131 cites W2062029885 @default.
• W3048751131 cites W2062530126 @default.
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• W3048751131 cites W2114155569 @default.
• W3048751131 cites W2121354606 @default.
• W3048751131 cites W2137771504 @default.
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• W3048751131 cites W2179610174 @default.
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• W3048751131 cites W2272802497 @default.
• W3048751131 cites W2294646523 @default.
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• W3048751131 cites W2471690043 @default.
• W3048751131 cites W2557242880 @default.
• W3048751131 cites W2563642244 @default.
• W3048751131 cites W2570396264 @default.
• W3048751131 cites W2590122001 @default.
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• W3048751131 cites W2908697626 @default.
• W3048751131 cites W2920438880 @default.
• W3048751131 cites W2937521746 @default.
• W3048751131 cites W2942651016 @default.
• W3048751131 cites W2942765605 @default.
• W3048751131 cites W2943158117 @default.
• W3048751131 cites W2947793684 @default.
• W3048751131 cites W2949420811 @default.
• W3048751131 cites W2951479258 @default.
• W3048751131 cites W2954589950 @default.
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• W3048751131 cites W3008481042 @default.
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• W3048751131 doi "https://doi.org/10.3390/molecules25163663" @default.
• W3048751131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7464317" @default.
• W3048751131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32796768" @default.
• W3048751131 hasPublicationYear "2020" @default.
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