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- W3048752454 endingPage "992" @default.
- W3048752454 startingPage "978" @default.
- W3048752454 abstract "The rapid development of microbial resistance to conventional antibiotics has accelerated efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial resistance. Intense nonclinical and clinical research is today ongoing to evaluate antimicrobial peptides (AMPs) as potential next-generation antibiotics. Currently, multiple AMPs are assessed in late-stage clinical trials, not only as novel anti-infective drugs, but also as innovative product candidates for immunomodulation, promotion of wound healing, and prevention of post-operative scars. The efforts to translate AMP-based research findings into pharmaceutical product candidates are expected to accelerate in coming years due to technological advancements in multiple areas, including an improved understanding of the mechanism-of-action of AMPs, smart formulation strategies, and advanced chemical synthesis protocols. At the same time, it is recognized that cytotoxicity, low metabolic stability due to sensitivity to proteolytic degradation, and limited oral bioavailability are some of the key weaknesses of AMPs. Furthermore, the pricing and reimbursement environment for new antimicrobial products remains as a major barrier to the commercialization of AMPs." @default.
- W3048752454 created "2020-08-18" @default.
- W3048752454 creator A5001825767 @default.
- W3048752454 creator A5052673794 @default.
- W3048752454 creator A5072856096 @default.
- W3048752454 date "2020-08-12" @default.
- W3048752454 modified "2023-10-12" @default.
- W3048752454 title "Antimicrobial peptides as therapeutic agents: opportunities and challenges" @default.
- W3048752454 cites W1482266509 @default.
- W3048752454 cites W1927671826 @default.
- W3048752454 cites W1966355489 @default.
- W3048752454 cites W1967631524 @default.
- W3048752454 cites W1970396769 @default.
- W3048752454 cites W1970713344 @default.
- W3048752454 cites W1975795847 @default.
- W3048752454 cites W1989989651 @default.
- W3048752454 cites W1989998611 @default.
- W3048752454 cites W1992542859 @default.
- W3048752454 cites W1995609813 @default.
- W3048752454 cites W1997152791 @default.
- W3048752454 cites W2001503866 @default.
- W3048752454 cites W2011434571 @default.
- W3048752454 cites W2012251902 @default.
- W3048752454 cites W2013133956 @default.
- W3048752454 cites W2014287269 @default.
- W3048752454 cites W2024976212 @default.
- W3048752454 cites W2026482455 @default.
- W3048752454 cites W2028392511 @default.
- W3048752454 cites W2041958543 @default.
- W3048752454 cites W2048411919 @default.
- W3048752454 cites W2050000500 @default.
- W3048752454 cites W2050895876 @default.
- W3048752454 cites W2060412064 @default.
- W3048752454 cites W2068275014 @default.
- W3048752454 cites W2068699244 @default.
- W3048752454 cites W2072432297 @default.
- W3048752454 cites W2083212567 @default.
- W3048752454 cites W2083877661 @default.
- W3048752454 cites W2084845164 @default.
- W3048752454 cites W2088877201 @default.
- W3048752454 cites W2095407378 @default.
- W3048752454 cites W2097099115 @default.
- W3048752454 cites W2106449126 @default.
- W3048752454 cites W2107050135 @default.
- W3048752454 cites W2107811099 @default.
- W3048752454 cites W2112241193 @default.
- W3048752454 cites W2124580054 @default.
- W3048752454 cites W2133709240 @default.
- W3048752454 cites W2143969153 @default.
- W3048752454 cites W2159861471 @default.
- W3048752454 cites W2160780417 @default.
- W3048752454 cites W2164432723 @default.
- W3048752454 cites W2236056443 @default.
- W3048752454 cites W2243791289 @default.
- W3048752454 cites W2279718345 @default.
- W3048752454 cites W2337777524 @default.
- W3048752454 cites W2337957188 @default.
- W3048752454 cites W2338977647 @default.
- W3048752454 cites W2342937250 @default.
- W3048752454 cites W2346303632 @default.
- W3048752454 cites W2346680648 @default.
- W3048752454 cites W2460182520 @default.
- W3048752454 cites W2471768058 @default.
- W3048752454 cites W2482435435 @default.
- W3048752454 cites W2519208473 @default.
- W3048752454 cites W2522297362 @default.
- W3048752454 cites W2536926250 @default.
- W3048752454 cites W2541965170 @default.
- W3048752454 cites W2548197444 @default.
- W3048752454 cites W2559271087 @default.
- W3048752454 cites W2560676632 @default.
- W3048752454 cites W2562261325 @default.
- W3048752454 cites W2579968578 @default.
- W3048752454 cites W2588261767 @default.
- W3048752454 cites W2605235260 @default.
- W3048752454 cites W2610299066 @default.
- W3048752454 cites W2611768739 @default.
- W3048752454 cites W2617456826 @default.
- W3048752454 cites W2724823461 @default.
- W3048752454 cites W2743060657 @default.
- W3048752454 cites W2747741021 @default.
- W3048752454 cites W2752567037 @default.
- W3048752454 cites W2760887315 @default.
- W3048752454 cites W2765092674 @default.
- W3048752454 cites W2767403660 @default.
- W3048752454 cites W2767698222 @default.
- W3048752454 cites W2782456186 @default.
- W3048752454 cites W2782495818 @default.
- W3048752454 cites W2783981376 @default.
- W3048752454 cites W2788314593 @default.
- W3048752454 cites W2791781902 @default.
- W3048752454 cites W2795098196 @default.
- W3048752454 cites W2797390629 @default.
- W3048752454 cites W2802615151 @default.
- W3048752454 cites W2804952668 @default.
- W3048752454 cites W2805873552 @default.
- W3048752454 cites W2806711088 @default.
- W3048752454 cites W2806925866 @default.